Waiting : Gleason 9. Not spread... - Advanced Prostate...

Advanced Prostate Cancer

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NFHS profile image
NFHS
13 Replies

Gleason 9. Not spread. Surgery for April 1. Does Lupron shot prevent spread while I wait till April?

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NFHS
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13 Replies
GP24 profile image
GP24

Yes, it will. However, you have to take Casodex before the Lupron shot.

NFHS profile image
NFHS in reply to GP24

Thanks!

Ahk1 profile image
Ahk1 in reply to GP24

Why casodex?

Is it always necessary with lubron?

Thanks

GP24 profile image
GP24 in reply to Ahk1

The American Cancer Society writes:

cancer.org/cancer/prostate-...

When LHRH agonists are first given, testosterone levels go up briefly before falling to very low levels. This effect is called flare and results from the complex way in which these drugs work. Men whose cancer has spread to the bones may have bone pain. If the cancer has spread to the spine, even a short-term increase in tumor growth as a result of the flare could press on the spinal cord and cause pain or paralysis. Flare can be avoided by giving drugs called anti-androgens (discussed below) for a few weeks when starting treatment with LHRH agonists.

Lupron is an LHRH agonist.

Ahk1 profile image
Ahk1 in reply to GP24

Thank you, sir.

Tall_Allen profile image
Tall_Allen

Yes. The treatment that has the best outcomes for gleason 9 is brachy BOOST therapy, but it is not available everywhere:

pcnrv.blogspot.com/2018/03/...

NFHS profile image
NFHS in reply to Tall_Allen

Thanks!

NFHS profile image
NFHS

Thanks!

tallguy2 profile image
tallguy2

Never had Casodex, just Lupron/Eligard.

When you say "not spread" please elaborate...how do you know this?

Best wishes!

NFHS profile image
NFHS in reply to tallguy2

CAT Scan and Bone Scan showed no spread.

tallguy2 profile image
tallguy2 in reply to NFHS

That is excellent news!

Stegosaurus37 profile image
Stegosaurus37

Everybody is different and normally, yes, lupron will help. There is always the 10%, however - like me - where lupron, while lowering the testosterone to unmeasurable levels, won't do a damn thing for your cancer. When I went on lupron my testosterone went to zero and my PSA went form 19 to 45. Nobody knows what will work or what won't. Take your best shot and if that doesn't work, try something else.

But always remember - attitude is everything.

Mkeman profile image
Mkeman in reply to Stegosaurus37

Go to Foundation One website and see if a genetic study might point to a treatment regimen. if insurance doesn’t cover...they will do the whole study for $3500 self pay.

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