PSA decreased from 1.4 to .355 in one month after going back on ADT after five month holiday . This time trelstar only; stopped casodex and dutasteride. Had sbrt to two bone nets.
So I’m still castrate sensitive (T = 9.0) after 4 1/2 years of IADT and SRT to mets discovered on each holiday in 2015, 2017 and 2018.
See profile for details. The one major positive seems to be that I have low volume mPCa ( oligomets).
So the question is “should I fix something that ain’t broken” or should I try to drive PSA down to zero? At this point I don’t think I’ll take any more ADT holidays but I can’t help but wonder if the holidays , albeit brief, have prolonged the efficiency of first line ADT?
Great news Bob! When I visited Johns Hopkins last fall they talked about the importance of ADT holidays - to give you a break from the side effects and presumably to lengthen the time that the cancer is sensitive to HT. Glad to see the theory worked in practice in your case.
I've yet to start long term ADT but certainly plan to incorporate these holidays when I do. Just curious...during your holidays, how far does your T levels rebound? I was on ADT for 6 months a few years back in conjunction with adjuvant RT. My T levels rebounded slowly, getting back to "normal" in about 6 months after it ceased.
Mine never gets back to normal in six months . Typically not more than 100