My dad was treated with radiation seeds at 71. Put on Lupron at 75. PSA always hung in there and was given a bone scan and Cat scan 1/12/17. All was clear. On 9/19 he had his blood work checked and PSA was below 1. Went back for his 3 month blood work in December and PSA was 13. Had a bone scan done and Cat scan. He now has cancer in most bones. Neck / spine / ribs / etc. They put him on Zytiga / Predisone and are continuing Lupron as well. Has anyone had a similar story and how has the success been. Thank you.
Just looking for some input - Advanced Prostate...
The original Clinical Trial for Zytiga (abiraterone acetate) for patients with metastatic castration-resistant prostate cancer who had not received previous chemotherapy was the COU-AA-302 Study. (Lead author was Dr. Charles Ryan who was then at UCSF, and has since moved to the Mayo Clinic.)
The statistics of Adverse Events and side effects experienced by roughly 540 men in each arm of the trial are listed in the "Safety" section of this link, and in Table 2 and Table 3.
Keep in mind that these are aggregate group statistics, and individual results may vary.
Men here may share their anecdotal personal experiences. Many would probably agree that subsequent scans and PSA/Alk Phos test results are likely to give some indication as to whether the added Zytiga is having a positive effect on suppressing whatever may be the biology of his current metastatic disease.
(With confirmed bone "mets", he might also ask his doctors about one or the other of the bone agents Xgeva (denosumab) or Zometa (zolendronic acid).)
Here's hoping it works really well, with very minimal side effects. Keep us posted.