Has anyone become castrate resistant by taking Avadart only ?

[George71]

One Dr. told me yes, one said no.

[Tall_Allen]

How can you be castration resistant if you aren't castrated (chemically or physically)?

[George71 in reply to Tall_Allen]

apparently some Dr.s think that taking Avadart over time will result in androgen independent prostate cancer similar to taking ADT for 2 or 3 years.

[George71 in reply to Tall_Allen]

This is from the article:

"The research team also described preliminary data that for those with a very low PSA on study entry, there was no improvement from PLNRT+PBRT+STAD over PBRT+STAD; although, this was an unplanned analysis."

[Tall_Allen in reply to George71]

What are you talking about?

[George71 in reply to Tall_Allen]

the quote was from the article you cited:

The NRG Oncology/RTOG 0534 SPORRT clinical trial

astro.org/News-and-Publicat...

[Tall_Allen in reply to George71]

This is a post about Avodart

[Break60 in reply to George71]

This post shows results of SPPORT trial concluding benefit from SRT to pelvic lymph nodes as well as prostate bed plus short term ADT !!

[cesanon]

I don't know if this is responsive to your question, but...

When I was moving from Dr. Myers to Dr. Sartor, Myers had me on long term Avodart and Sartor took me off of Avodart. His rational was that all it would do is promote more mutational experimentation by the cancer cells.

I took this to mean that Sartor thought it was the equivalent of a low level form of ADT.

Whatever Sartor's reasoning, Myers seemed to accept Sartor's differing approach to long term Avodart use by me as a rational and reasonable one.

[George71 in reply to cesanon]

Yes, that was what I have been told by Dr. Sator also.

On the other hand my OC at M D Anderson said he thought it was ok if I thought it was helping. The RO said he thought it didn't help... it just masks the PSA.

The truth is that everything we do has an effect on cancer cells one way or the other and doing nothing seems worse than doing the mildest form of treatment to slow down the growth. Anything we do to try and inhibit the cancer progress that works will cause it to try and mutate around it over time. I am looking for anything that slows cancer growth and lowers PSA without lowering testosterone and Avadart is the only thing I know that does that. I think Dr. Sartor is right to be very cautious about taking anything that may lead to castrate resistant Pc.

I think you had said in a prior post that you got off Avadart and went on high T with Dr. Sartor and your PSA shot up ? If not please fill me in. I was thinking about ultra high T to see if it would cause the cancer to become dormant. I read that it it cells are gorged with T they cannot expel all the T necessary to execute a new cell reproduction cycle. Is that the theory?

[cesanon]

"I think you had said in a prior post that you got off Avadart and went on high T with Dr. Sartor and your PSA shot up ?"

That was someone else. But Sartor is doing high t with patients. And has experience doing bipolar testosterone.

He is probably a go to doc for anyone interested in that.

[George71 in reply to cesanon]

when you stopped the Avadart did your PSA go up?