The below gathered and condensed from the Univ. of Chicago Medical Center, and the National Health Research Institutes, in Taiwan: provides the positive use of Bee Propolis. This material comes from the bee's internal production of a waxy material used to repair their hives. It is understood that the full biological effects are lacking in these over the counter compounds. As one can easily purchase Bee Propolis in capsule form or raw form.
Now the active ingredient or chemical in Bee Propolis has been determined to be Caffeic Acid Phenethyl Ester. Below I will use the term CAPE for this compound. Dr Chuu in Taiwan showed that in low concentrations CAPE successfully slowed the proliferation of cultured prostate cancer cells isolated from human PROSTATE TUMORS.
CAPE was also effective at slowing the growth of human prostate tumors grafted into mice. The use of CAPE reduced Tumor Size in half, within 6 weeks. But when stopped the tumors began to grow again. The conclusion, was that Bee Propolis[CAPE], suggested that CAPE, stopped cell division, rather than killing cancer cells.
So in a paper yet to be produced by me here on Killing Dormant/Stem Cells, it is possible that CAPE could be a part of at least stopping the advancement of Dormant Pca cells.
The researchers created their own Western Blot type system to measure proteins and protein changes, in their tests. This reduced costs severely for their work. They were looking for cellular pathways involved in Pca Tumor growth. Using these methods, the researchers were able to determine the arresting of Cell Growth was due to the suppression of proteins in the p7056 kinase, and the Akt pathways, which are important sensors for getting sufficient nutrition, that can trigger cell proliferation.
One of my proposals from a few months ago was focused on trying to starve the cells that we consider Dormant, when we are Undetectable as to PSA. As I proposed that they were not sleeping, yet in a low state of metabolism, yet feeding to at least stay alive, as they needed just enough glucose to produce Lactic Acid to maintain their internal pH of 6.7
It appears CAPE basically stops the ability of prostate cells to sense there is nutrition available. The ability of CAPE to freeze cell proliferation, could make it promising as a co-treatment with Chemo--where the CAPE stops growth and the Chemo kills the rest.
It is too bad IMO that the tests did not go beyond 6 weeks, as Pca cells may be able to survive without nutrition, when it is blocked by going into a low Metabolism state, to reserve its energy, and stay alive. I can see long term use for a year, whereby unproven, that certain Pca cell lines in Tumors would have 2 choices if nutrition is blocked ---go Dormant, to survive, or Die. But the tests were not long term, and there has been no follow up. They did provide though, new alternatives to the typical Western Blots. If you are going to ask me if I use it--I can say it is available at Amazon, under the terminology of Bee Propolis.