We talk of Gene mapping back and forth in between posts, and many men here have been mapped or evaluated, either by the Guardian 360, or the Foundation One methods.
As many are aware there are a good many targeted drugs being used against identified Gene Mutations. Regardless if passed down in the family line or naturally occurring as per an individual that may have developed them.
The most famous today is Olaparib, originally developed and used against BRCA-1-2 for women's breast cancer---and now being used I believe still off label, for men with Pca, and also presenting the BRCA-1-2 mutations.
A recent Study out of Scandinavia evaluated men who were Gene mapped, and had identified Gene Mutations, against men who were not Gene Mapped, but very likely to have Gene Mutations. The Mapped Men, were treated with Targeted Immunology drugs specifically chosen for use against their mutations. The Unmapped Men were given best guess Immunology Drugs, against their suspected unknown Mutations.
All men were castrate resistant and metastatic. TTF[Time to Failure], for the treatment was the end point result looked for. The results were that the TTF was 2 times longer for the men who were Gene Mapped, and had Targeted Drugs chosen specifically against their Gene Mutations, over the men who received best guess targeted drugs against suspected Gene mutations.
[Bottom Line is obvious: lets Get Gene Mapped]. I was Gene mapped within 60 days of my Initial RP. There are as I reported earlier, approximately world-wide 290 drugs in trials, and another approximately 2,900 in lab tests as to; In Vitro, and in Vivo, with small lab mammals. There is an Immunology Drug development revolution in progress.