antihypertensive drug syrosingopine enhances metformin's anti-cancer efficacy.

[rassusukumaran]

Came across this on Metformin and syrosingopine. I have been taking 1000 iu of metformin a day in two doses. Could the wise ones on this forum share their thoughts on this report? I am Metastatic and CRPC and currently on Zytiga after 12 years of diagnosis. I dread the day when it may stop working as it usually does after about 9 months. I am wondering as to what would be a good dosage of syrosingopine to take together with metformin.

medicalxpress.com/news/2018...

[pjoshea13]

"Many tumor cells shift their metabolism toward glycolysis, which means that they generate energy mainly via the breakdown of glucose to lactate. Since the accumulation of lactate leads to a blockade of the glycolytic pathway, cancer cells eliminate lactate by exporting it from the cell via specific transporters."

As you might know, PET scans using fluorodeoxyglucose (FDG) are not very useful in PCa. Although cells can shift to glycolysis, PCa is the exception to the quote above.

An FDG-PET scan would indicate the degree to which syrosingopine [1] might "block the two most important lactate transporters and thus, inhibit lactate export".

Full text of new study: [2].

Another Swiss study is the reason that many of us use 2,000 mg Metformin daily [3].

Doubling your current dose might enhance metformin's anti-cancer efficacy.

-Patrick

[1] en.wikipedia.org/wiki/Syros...

[2] sciencedirect.com/science/a...

[3] ncbi.nlm.nih.gov/pubmed/244...

[rassusukumaran in reply to pjoshea13]

I thank you for your informed comments. You are so resourceful. Thanks again. Do you think to take Syrosingopine ( if I can get it) would involve any extra risk or interfere with Zytiga pathway

[pjoshea13 in reply to rassusukumaran]

I can't answer that. -Patrick

[gusgold in reply to pjoshea13]

Pat,

So, it looks like taking a NAD+ supplement would be a bad idea for PCa. Is this correct

Gus

[pjoshea13 in reply to gusgold]

Gus,

Perhaps a bad idea for other cancers. However, if you have cells that have converted from fatty acids to glycolysis, best to avoid. This could very well be the case in CRPC.

Note:

"SIM+MET {simvastatin and metformin } treatment and subsequent AMPK activation inhibits aerobic glycolysis and macromolecule synthesis, impeding CRPC growth, proliferation, and metastasis. The lack of nutrients starves the C4-2B CRPC cell, and prevents progression beyond the G1-phase cell cycle checkpoint, leading to G1-phase cell cycle arrest."

ncbi.nlm.nih.gov/pmc/articl...

-Patrick

[cesanon in reply to pjoshea13]

Talked to my Doc about syrosingopine.

He thought it was a really bad idea. There is a reason no one uses it anymore.

It has really bad side effects. No one even appears to sell it anymore.

[ruediger2010 in reply to cesanon]

I have contact with Dr.Ben Benjamin for his study about Metformin and Syrosingopine.1mg Syrosingopine dayly ist enough combined with Metformin 2x 800 mg to help killing the stammcells of cancer.Syrosingopine you can order in Switserland :1000 capsules from 1mg cost 5000,- Euro.I hoop i can help you a Little bit.No guarantee that will help humans cancer!!!But sometimes is no other way.Greetings from Germany.Volksapotheke Schaffhausen ,Switzerland

[cesanon in reply to ruediger2010]

I think it would make more sense for someone to do a current trial. Then put it on the market as a generic. Apparently it has already been approved for blood pressure.

[ruediger2010 in reply to cesanon]

For a new Trial you must have a lot of Money.In the next 2 years Dr.D.Benjamin didnt expect a new Trial.

[cesanon in reply to ruediger2010]

It's already approved. It would cost a lot less than normal trials.

[ruediger2010 in reply to cesanon]

Wrong again,Dr.Don Benjamin cant find Syrosingopine in pharmaceutical Quality all around the world for his Trial.So he told me,that the Syrosingopine he used for the Trial must make in a Special Laboratory and that cost a lot.And that is exactly the same that told me in the apotheek in Switzerland.It is a very complicated and expensiv proces to make from industrial Syrosingopine a Pharmaceutical Syrosingopine.

[cesanon in reply to ruediger2010]

He needs to partner with a generics pharma that will make money if the trial is successful.

Unfortunately this is something I can't help with at a distance. And, in my experience, I probably probably couldn't help if I was inside either.

Itinerate docs are just so difficult to work with. They think it is all about them, and what they do, when instead it is about the money.

Well hopefully he will succeed anyways. But it will be hard unless he understands he has 2 concurrent equations to solve, one is the science, and the other is the money. And I guess the third is regulatory.

[RGereck in reply to ruediger2010]

Can you give us a number, address or email to acquire syrosingopine? I live in America and it is not available here. Thank you, Bob

[toobs1234 in reply to pjoshea13]

This may oversimplify the situation. It seems that metformin disrupts the mitochondrial electron transport chain (as does green tea), but cells can switch to glycolisis for ATP proruction. Syrosingopine seems to shut down this option as well.

ncbi.nlm.nih.gov/pmc/articl...

[pjoshea13 in reply to toobs1234]

Thanks for the link. -Patrick

[GP24]

Don Benjamin did a mouse trial. What works with mice very often will not work in humans. Plus there is no way to purchase Syrosingopine from a pharmacy.

[ruediger2010 in reply to GP24]

wrong,you can get it in Switzerland on the Volksapotheke in Schaffhausen.1000 Tablets of capsules kost 5000,-Euro.Give a call and the will produceed for you!!

[ewhite999 in reply to ruediger2010]

Ruediger2010, please notice the tone your fellow cancer battlers use on this site. We are quite civil to each other which makes for a pleasant and typically rewarding experience.

[ruediger2010 in reply to ewhite999]

I think i was civil,i didnt speak good english ,you can see on my reply and i want to help to give a adres you can buy Syrosingopine.So good buy for ever if you think i will do something wrong.

[ewhite999 in reply to ruediger2010]

Understood. Appreciate your contribution

[GP24 in reply to ruediger2010]

Rüdiger,

you wrote above: "Dr.Don Benjamin cant find Syrosingopine in pharmaceutical Quality all around the world" - so I was not all wrong. But thank you for the link to the Volksapotheke! Very interesting but too expensive for a patient just to give it a try to see if it works.

How do you know that 1mg Syrosingopine daily ist enough combined with Metformin 2x 800 mg? Has there been a dose-escalation study by Dr. Benjamin?

I did a lot of reading about Syrosingopine but could not give it a try, the pills are withdrawn from the market. As far as I could make out Syrosingopine was not withdrawn due to side effects, it just did not have efficacy with hypertension.

Do you know of any human that has already tried to take Syrosingopine for prostate cancer?

[GP24 in reply to ruediger2010]

Here is a report of a new study regarding Syrosingopine:

sciencedaily.com/releases/2...

This study was done together with the pharma company "Basilea Pharmaceutica International Ltd". Did Dr. Benjamin tell you that this company will support additional trials?

[toobs1234]

In their 2016 paper, the authors tested 4 different prostate cancer lines in vitro and 3 of them were responders. Only the pre-malignant WPE1NA22 line was not.