'Just as I expected' ...: New... - Advanced Prostate...

Advanced Prostate Cancer

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'Just as I expected' ...

pjoshea13 profile image
2 Replies

New Australian study below.

Can expectations induce side effects?

"Previous research has indicated pre-treatment response expectancies of side effects often predict subsequent toxicity severity. However, this has been largely based on female patients undergoing chemotherapy."

Ah well, but men are different. LOL

"In this older male sample, response expectancies of side effects predicted experiences throughout treatment, including the period before toxicities were medically expected. Response expectancies of sexual side effects were robust, independent predictors of subsequent toxicities across treatment, especially issues with orgasm; warranting focus in practice and future research."

-Patrick

ncbi.nlm.nih.gov/pubmed/304...

J Pain Symptom Manage. 2018 Nov 14. pii: S0885-3924(18)31063-7. doi: 10.1016/j.jpainsymman.2018.11.002. [Epub ahead of print]

'Just as I expected': A longitudinal cohort study of the impact of response expectancies on side effect experiences during radiotherapy for prostate cancer.

Devlin EJ1, Whitford HS2, Denson LA3, Potter AE4.

Author information

1

School of Psychology, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address: elise.devlin@adelaide.edu.au.

2

School of Psychology, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia; University of South Australia Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia.

3

School of Psychology, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

4

Adelaide Radiotherapy Center, Adelaide, South Australia, Australia.

Abstract

CONTEXT:

Previous research has indicated pre-treatment response expectancies of side effects often predict subsequent toxicity severity. However, this has been largely based on female patients undergoing chemotherapy.

OBJECTIVES:

We tested whether this association also occurred in a novel cohort; men with prostate cancer undergoing radiotherapy. We investigated these associations throughout treatment (before and after side effects were medically predicted to occur), controlling known and novel variables.

METHODS:

Homogenous male patients scheduled for radiotherapy (N = 35, mean age 71 years) completed baseline (pre-treatment) measures; response expectancies of 18 treatment-related side effects, questions about baseline health and hormonal treatment, emotional state, and coping style. Response expectancies of the side effects were again measured 2-weeks into treatment. The severity of the same 18 toxicities were assessed 2- and 7-weeks into treatment.

RESULTS:

Hierarchical multiple linear regressions revealed baseline response expectancies significantly and independently predicted 6 of 18 toxicities 2-weeks into radiotherapy, contributing 12-30% of explained variance (β=0.39-0.59). Response expectancies assessed 2-weeks into treatment significantly and uniquely predicted 7 of 17 experienced toxicities at 7-weeks, explaining 17-50% of variance (β=0.49-0.91). Sexual toxicity response expectancies revealed the strongest associations with experience throughout treatment (β=0.46-0.91), with 'inability to reach orgasm' showing the largest effect.

CONCLUSION:

In this older male sample, response expectancies of side effects predicted experiences throughout treatment, including the period before toxicities were medically expected. Response expectancies of sexual side effects were robust, independent predictors of subsequent toxicities across treatment, especially issues with orgasm; warranting focus in practice and future research.

Copyright © 2018. Published by Elsevier Inc.

KEYWORDS:

expect; nocebo; oncology; psychology; radiotherapy; sexual dysfunction

PMID: 30447387 DOI: 10.1016/j.jpainsymman.2018.11.002

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pjoshea13
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GP24 profile image
GP24

Wikipedia mentions the nocebo effect:

en.wikipedia.org/wiki/Nocebo

One patient took part in a clinical trial. He decided he wanted to die and took all the pills at once which he had got for the entire month. So he got very sick and they took him to the ER. There they called the trial administrator to learn what they could do to help the patient and learned that he was in the placebo arm. The patient recovered very quickly and went home.

rococo profile image
rococo in reply to GP24

If there is any truth to the nocebo effect, those tobbaco ads can be doing lots of harm. How can one differentiat from true side effects and nocebo. Answers please. Rocco

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