Zytiga over Xtandi

[Blair77]

As I understand Zytiga and Xtandi have similar efficacy. However, side effects for Xtandi seem less severe. I notice lots of people on Zytiga but not Xtandi. Does anyone know why Zytiga seems to be prescribed more?

[Tall_Allen]

it's cheaper. Insurance prefers the patient tries it first.

[pjoshea13]

A doctor told me that a greater percentage of his patients had a problem with Xtandi. i.e. non-trivial side effects.

-Patrick

[StephjoeSteph4197]

It was opposite for my husband. Zytiga was good for my husband. Xtandi has more side effects for him.

[Hidden]

I believe Xtandi was just approved in 2017 to use for prostate cancer non metastatic cancer and before June of 2017 patients needed to have known metastatic cancer.

[leo2634]

Zytiga works for me with minimal side effects, was never prescribed Xtandi. My MO said they perform in the same fashion but he said that in his experience the Zytiga was tolerated more easily by his patients.

[vandy69]

Good Friday Morning Blair77,

I have been in this battle for almost six years (please see bio for complete treatment history).

Had Zytiga way back in January 2013 when it was first approved for prechemo metastatic PCa. It blocks production of testosterone from testes and adrenal glands. I got about 18 months from it.

Xtandi is like a super Casodex, in that it blocks the androgen receptors in the cancer cells. I got about 12 months from it the first time. After chemo completed in January 2018, tried a rechallenge with Xtandi, and with God's miracle, it is working a second time.

Best wishes. Never Give In.

Mark, Atlanta

[George79]

When my Zytiga with minimal side effects stopped working after 18 months was switched to xandi. Constant nausea and it didn’t work. Everyone is different.

[Magnus1964]

I have tolerated both rather well. Casodex is also an option. All three work in different ways against prostate cancer.

[Shooter1]

On Xtandi reduced dose. My body won't tolerate 160 mg but 120 seems to work. 160 and constant 24/7 pain in belly and feet, no energy at all, couldn't work. 120 is marginal for tolerable side effects but can stand them for now...pain in every fingertip, numb and swollen feet, but from my ankles to my wrists I am way better. Able to go back to work., May have to drop to 2 pills one day and three the next to get even better, but need to follow with blood tests for a while to monitor response. PSA still dropping at last test after cutting dose.

Doug

[tallguy2]

My father has a seizure on Xtandi so I'm going straight for the Zytiga (after Taxotere chemo), steroids and all.