ROS and the effect on Prostate cancer

[George71]

tandfonline.com/doi/pdf/10....

ROS vs. metastases. In many types of tumors including prostate

cancer, melanoma and breast cancer, the increased metastatic ability

of tumor cells is positively related to their intracellular ROS level.

Exogenously administration of ROS would enhance certain stages

of metastatisis,

29

while anti-oxidant treatment could attenuate

metastatic progress.

30

Even surgical procedures, a primary option

for treating tumors, can lead to the increased growth of metastatic

tumors by ROS generation.

13

Possible mechanisms involve aber-

rant expression of integrins and MMPs and suppression of anoikis,

as indicated by in vitro studies.

15

Intriguingly, Ishikawa K. and his

colleagues recently have provided direct evidence to confirm the

causative relationship between ROS and tumor metastasis. After

replaced with mitochondria DNA (mtDNA) derived from a highly

metastatic mouse tumor cell line, an originally poorly metastatic

cell line acquires the metastatic potential. The transferred mtDNA

contain mutations producing a deficiency in respiratory complex I

activity and are associated with overproduction of ROS. Pretreatment

of the highly metastatic tumor cells with ROS scavengers suppresses

their metastatic potential in mice.

[pjoshea13]

You have three choices:

1] Attempt to treat cancer ROS with antioxidants, but that might interfere with therapies that rely on increasing ROS.

2] Attempt to increase ROS to killing levels via pro-oxidant doses of antioxidants.

3] Do nothing. Perhaps sit back & wait for a study you approve of.

For men who are not at high risk for PCa-related mortality [3] might be OK.

For the rest, a passive approach seems overly optimistic. I do not intend to "go gentle into that good night" & I opt for [2].

-Patrick