My husband is wrestling with a looming recommendation of a second course of chemo with carboplatin. He did Taxotere early on (CHAARTED protocol). Did great on Xtandi for 2 years, now trying Zytiga (although we've been told it might not work, or work for long). He's resisting the idea of chemo because he thinks he will feel like crap during the chemo and won't get any real quality of life benefit after that -- just a longer, suffering life.
Note: He is only 56, very healthy otherwise, but his blood values really suffered during the Taxotere, and also the RA223/Xofigo therapies. He got Neupogen which kept him on schedule with the chemo (so I guess not as bad as some people) but his low blood counts get him really anxious.