I've been following and searching the site for some time before joining. I appreciate the information and updated responses. I am 59 years old, I was diagnosed stage IV with extensive bone mets in spine, pelvis, skull, ribs, shoulders. 18 weeks chemo with good results reducing PSA down to under 1.0 and much of the cancer reduced or gone except the spine area. One hundred day checkup after chemo, PSA up to 6.71, no new growth of cancer but regrowth of remaining spots on spine. Started Zytiga one week ago. I really don't know what to expect, seems like Zytiga is a Hail Mary pass as it works on some, not on others, and no one really takes it for extended years from what I can read in previous posts. Hoping for a long journey, fearing it won't be.