Fat.: I began writing this yesterday... - Advanced Prostate...

Advanced Prostate Cancer

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Fat.

pjoshea13 profile image
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I began writing this yesterday after seeing the Daily Mail headline:

- "Fatty Western diets make prostate cancer more aggressive"

This from a newspaper that advised men to drink flaxseed oil to avoid PCa. Ugh!

After a while, I became weary of the subject & the stupidity of the media, so listened to some music instead.

Anyway, Kuanyin's post:

- "It's The Fat, Stupid!"

has drawn me back in. Rather than replying to him with a post that would not be read by those who have already read his post & moved on, this is a separate thread.

...

In the Pandolfi-Chen study [1], we discover something interesting about metastatic PCa.

It is common knowledge that PTEN is often inactivated in PCa.

Note: PTEN (phosphatase and tensin homolog) is a tumor suppressor gene. [2]

There are over 1,300 PubMed hits for <prostate PTEN>. We know a lot about PTEN.

[3] (1997) - Johns Hopkins - "Frequent inactivation of PTEN/MMAC1 in primary prostate cancer."

[4] (2017) - Netherlands/USA - "PTEN loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profiles."

& so on.

We know far less about PML (promyelocytic leukaemia), which is also a tumor suppressor gene.

From what I read in the study abstract [1], it is possible to have PTEN-null indolent PCa, but if PML is silenced too, the cancer becomes aggressive. AND, this involves the cancer cells manufacturing lipids. At least in the mouse model.

Note: Yes, PCa is able to make fats. To do this, it needs enzymes from the fatty acid synthase [FAS] complex. Back in 1995, Partin at Johns Hopkins reported [5] that FAS "predicted pathologic stage well when analyzing primary prostate cancer in radical prostatectomy specimens" & "is one of the few markers that provides additional predictive information beyond that of the Gleason score".

[6] (2017 - Russia) - "the high frequency of FASN expression in hPIN and cancer and no expression in most structures of benign hyperplasia make it possible to use this protein as an additional marker in the differential diagnosis of prostatic neoplasms."

So we can infer that prostate cells normally do not make fatty acids, & that the extent of FAS expression is indicative of how aggressive the cancer is.

[7] (2017) - U.S. - "Increased de novo synthesis of fatty acids is a distinctive feature of prostate cancer ... Therefore, inhibition of de novo fatty acid synthesis represents an attractive strategy for chemoprevention of prostate cancer. We have shown previously that dietary feeding of phenethyl isothiocyanate (PEITC), a phytochemical derived from edible cruciferous vegetables such as watercress, inhibits incidence and burden of poorly differentiated prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) model."

"The current study is the first to implicate inhibition of fatty acid synthesis in prostate cancer chemoprevention by PEITC."

So far, we have seen that the fat problem is a PCa cellular issue, & that the solution perhaps involves inhibition of FAS, & that we might be able to do that by consuming watercress.

Note: When cruciferous vegetables are cooked, the enzyme that liberates the active chemical is destroyed. Fortunately, watercress is usually eaten raw. The best way to liberate the maximum amount of PEITC is via a blender. Chewing is hit or miss, especially with my teeth. One approach I have used is to fill an ice cube tray with puree. Allow a cube to thaw each day before a fatty meal & swallow the stuff with the meal. The fat in the meal is essential for uptake.

...

How did a study about PTEN & PML suddenly segue to a "Western HFD" (high fat diet)?

The research team seems to have had a Eureka moment when they discovered the importance of PCa-manufactured fatty acids. "What if fat is the problem?" So they fed the mice a high fat diet, which made the cancer more aggressive.

The thinking, methods & language of these guys is so sloppy, that I am tempted to go back to my music in disgust.

What is a "Western HFD"? It is well known (& oft repeated) that Asians rarely get PCa until they move to America & adopt a Western diet. My experience of immigrants in the U.S., such as it is, is that we do not stray that far from our native diets. What changes with migration is affluence - we eat a little more of something & a little less of something else. One need only look at the increasing rate of PCa in the expanding middle classes in certain parts of the world. A frugal peasant diet is PCa-protective, it seems.

What is meant by a "Western HFD", as opposed to an Inuit HFD, say, which happens to be protective? The common definition is that it includes high-fat dairy.

In 2016, when my wife was seriously ill, I became well-acquainted with local supermarkets. The dairy aisles had an amazing selection of plain yogurt (one of the few things that my wife could then tolerate). Every brand had a 2% & zero fat version, but only one also had a product that was not fat-reduced. One supermarket did not have any full-fat yogurt at all.

& the aisles were full of NO-Fat & LO-Fat products. Raw meats were trimmed of almost all fat. & so on.

It's the logical conclusion of the Ancel Keys campaign against saturated animal fat - the vilification of fat itself. The U.S. food pyramid has fat at its apex & grains at the base. The fatter the population becomes, the more people turn to the pyramid, & fat-free products. What exactly is an American "Western" diet at this point?

Anyway, the study authors seem to buy into "the notion that a Western HFD can promote metastasis." So they fed the mice a HFD. What does HFD mean, in a murine context?

We have a number of old mice studies that showed that you could always improve survival by reducing the fat content of the diet.

Steve Freedland, who has been involved in some important studies, asked a simple question - does the type of fat matter? He discovered that the fat in commercial chows used by labs was corn oil. Does anyone here use corn oil anymore? It is high in linoleic acid [LA] a pro-inflammatory omega-6 fatty acid, precursor of the deadly arachidonic acid [AA] that is freely taken up by PCa cells when there is little or no omega-3 EPA-DHA.

[8] "Epidemiologic studies suggest that increased dietary fat consumption has a negative effect on PCa outcomes; however, it is unclear to what extent the type of dietary fat consumed influences disease initiation and progression. Indeed, both population-based and xenograft studies have suggested that fish oil consumption decreases PCa risk. Other studies have shown that, when using a corn oil-based diet, decreasing total dietary fat increases survival in a xenograft model. In contrast, another study demonstrated no improvement in PCa outcome when the amount of dietary fat was decreased using a saturated fat-based diet. This raised the hypothesis that, in addition to the amount of dietary fat being important, the type of fat mattered too. Thus, we sought to systematically examine the effects of various types of fat on PCa progression. We found that male mice xenografted with LAPC-4 tumors fed a diet in which the dietary fat source was fish oil outlived mice fed diets composed of corn oil, olive oil, or animal fat; survival was similar across the non-fish oil groups."

In the new study, it is meaningless to speak of a high fat diet without specifying the fatty acid components.

...

For those who are taken in by the headlines resulting from the new study, a 10% fat Dean Ornish vegan diet is the obvious next step.

Cows are vegan. Grass-fed cows don't build a lot of fat, but the fat is not from the diet. Most beef cattle in the U.S. go to feed lots before slaughter. They are typically fed corn &/or soy to fatten them up. The idea of a high carbohydrate diet causing fat accumulation shouldn't seem that odd.

What happens when we eat a carbohydrate meal? Digestible carb turns to glucose. It can happen fast or it can happen slow, but there will be a glucose spike in the blood. The body acts quickly to get rid of the spike. The response includes an insulin spike to get glucose to cells that can use it. The kidneys will try to get rid of some of it. But, alas, the basic strategy is to get the glucose stored as fast as possible & out of the blood. The glucose is first converted to triglycerides & preferentially stored as visceral fat.

[9] "Excess carbohydrates in the body are converted to palmitic acid. Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. As a consequence, palmitic acid is a major body component of animals. In humans, one analysis found it to make up 21–30% (molar) of human depot fat"

It is ironic, that the more people stricly follow the food pyramid, the more fat the body creates. When there is a significant amount of fat in a meal, glucose enters the blood slower, over a longer period, & without the spike.

Conversely, the body does not respond with urgency when a high fat meal is eaten. There is no rush to store circulating fatty acids, & they are largely used directly for energy.

...

When Dr. Myers first began treating PCa, he favored a low-fat diet. He quickly switched to a Mediterranean diet, which is 40% fat. In a vlog post he said that his patients who remained on a low-fat diet did not do well.

There is a study in an older post where PCa benefit was shown in a Mediterranean diet with nuts. Nuts are high in fat, so I guess that Dean Ornish doesn't include many in his 10% fat meals. Nuts contain varying amounts of fat & have distinct fatty acid profiles. One needs to be aware of how profound fatty acid differences can be.

If Ancel Keys could have pointed to the most dangerous saturated animal fatty acid, he might have fingered stearic acid. It has a backbone of 18 carbons, each of which is fully hydrogenated. They make candles out of the stuff.

But let's make the smallest of modifications - dehydrogenate at the halfway point. That turns it into an omega-9 monounsaturated fatty acid. Instead of being rigid, it bends in the middle. The result is oleic acid, the major fat in olive oil. The supremely healthy fat, according to some.

In recent years, stearic acid has been found to be neutral in turns of cardiovascular health. The body can convert stearic acid to oleic acid (& vice versa). In many cancers, though, including PCa, the oleic:stearic ratio directly correlates with a poorer prognosis. Cancer seems to like oleic acid but not stearic acid, & I doubt that diet affects that.

It's a complicated subject because the body has its own ideas about the fatty acids it needs, & it can create most of them. The exceptions are the omega-6 & omega-3 fatty acids. That is one area where we have control.

-Patrick

[1] nature.com/articles/s41588-...

[2] en.wikipedia.org/wiki/PTEN_...

[3] ncbi.nlm.nih.gov/pubmed/937...

[4] ncbi.nlm.nih.gov/pubmed/291...

[5] ncbi.nlm.nih.gov/pubmed/781...

[6] ncbi.nlm.nih.gov/pubmed/284...

[7] ncbi.nlm.nih.gov/pubmed/282...

[8] ncbi.nlm.nih.gov/pmc/articl...

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pjoshea13
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39 Replies
Mrkharn profile image
Mrkharn

The way it was explained to me at Penn State in, about, 1974 is that carbohydrates are turned into glucose. The cells use that glucose as energy.

However, a diet of white bread is not a good choice with the above understanding. As Patrick explained how the glucose is converted to fat.

With whole wheat bread, the carbohydrates are digested more slowly and the body has a better chance of using that food for energy rather than storing as fat.

Incidentally, cows eating soy beans is not normal, neither.

Mark (vegetarian for 45 years).

Mrkharn profile image
Mrkharn in reply to Mrkharn

Sorry. I got a little carried away...cows are a wonderful machine for turning grass into meat. Soybeans is not the right food except for the purposes of mass producing cheap food.

Frankenski profile image
Frankenski in reply to Mrkharn

An aside: My landlord in Germany had several cows, grazing wearily in his pasture, read as back yard, munching all day on the grass. That's all well and good if you want beef that has a bitter taste like grass. These cows didn't drop doo-doo, they ejected fluid from their butts. We here, feed our cows grain, and they taste like it. And, poop like it.

Mrkharn profile image
Mrkharn in reply to Frankenski

What I intended to say, but got carried away again, is the cows digestive system is a very sophisticated engine that turns grass into cow food or rather a source of nourishment. With regards to your landlords cows, you’d probably adjust to it if not already eating the other stuff. And they do have an adjustment period when switching from hay (winter) to grass (summer) as you can imagine.

dockam profile image
dockam

Just read this: medicalnewstoday.com/articl...

Randy

Kuanyin profile image
Kuanyin

We have been down this road so many times that I can now walk the arguments blindfolded. Nothing new, except the two very recent studies I have cited. As usual, everyone will continue doing his thing, thinking that he is "right." Our disease is to complicated and idiosyncratic, even within the same individual, that we, at least in what we have left of our lifetimes, may never seen anything really conclusive. I'm sure that may members have gone into some kind of remission, on or off fat or on or off carbs. I have chosen to limit my carbs and reduce my fats ti absolute minimum with little or no saturated fat, with the exception of Omega 3 and some monosaturated fat. Up until now, this seems to have worked for me. I am not advocating a vegetarian diet (although my diet tends in this direction, but not vegan). I know you don't adapt everything you have presented to us in posts. You just keep us informed. I don't think that it really benefits our members to continuously hash out the same material coming to the same conclusions. Members can read what is posted and do their own research. If it's confusing to them, well, welcome to our world!

pjoshea13 profile image
pjoshea13 in reply to Kuanyin

Kuanyin,

As I mentioned, I almost gave up on the topic yesterday. When the media grabs hold of an obscure paper & misrepresents the findings, I feel that I should make an effort. But I might not have bothered if there were no posts on the topic.

The funny thing about the paper is that it was received by the journal 21 November 2016! Evidentally it wasn't thought to be particularly exciting. Or perhaps there were problems with the paper.

Anyway, the take home message for Daily Mail readers is that a low-fat diet will protect them from PCa. The real message is that aggressive PCa manufactures fatty acids, & this is not a good thing. This has been know for at least 20 years & no-one has ever suggested (including the current authors) that a low-fat diet will change the behaviour of those cells & lower mortality risk.

-Patrick

Kuanyin profile image
Kuanyin in reply to pjoshea13

First of all there are two papers mentioned. secondly, I purposely used the Daily Mail report because most people could understand it. There have been comments stating "how easy" it was to understand. Thirdly, using myself as a guinea pig, I make sure that the carbohydrates I consume are varied and complex, including lentils and rice mixtures and contain lots of fiber. Most of us do not My HA1-c , IGF-1 levels are on the lower range. Next time when I visit my oncologist, I will measure fasting insulin.

"Because many people don’t know how many calories they consume each day, the National Academy of Sciences established age- and gender-based dietary reference intakes, or DRIs, for fiber. These guidelines actually stem from the recommendation of consuming 14 grams of fiber per 1,000 calories, assuming most individuals within specific age and gender groups consume the recommended amounts of calories for those groups. The DRI for fiber for men and women through the age of 50 is 38 grams and 25 grams per day, respectively, while men and women over the age of 50 should reduce their daily fiber intake to 30 grams and 21 grams, respectively. These recommendations are based on the assumption that most men through the age of 50 consume about 2,700 calories per day, while most women younger than 50 average just under 1,800 calories per day.

"

I would venture to say that most Americans (males) are not getting 30 grams of fiber a day. Also, we really don't know the fiber content of many of these carbohydrate studies. If, as one individual who has answered your post says, "white bread" (Penn State, 1974), then all bets are off. Even if they used so-called "whole-wheat bread," which traditionally wasn't much more than white bread with caramel coloring, those studies are also not valid. Finally, should many of our members be consuming more than the recommended calories for their age, the amount of fiber goes up. Getting even 30 grams of fiber every day, takes some planning and effort. If your eating a predominantly high fat, meat-based diet it would be even more difficult to fit in all of that fiber. There's a connection between red meat and colorectal cancer, sans processed meat, also exists.

Frankenski profile image
Frankenski

My wife is fat.

in reply to Frankenski

Mine too. And I'm the one with cancer.

Frankenski profile image
Frankenski in reply to

ROFLMAO

j-o-h-n profile image
j-o-h-n in reply to Frankenski

Now that's Hysterical.

Good Luck and Good Health.

j-o-h-n Thursday 01/18/2018 7:45 PM EST

Mrkharn profile image
Mrkharn in reply to Frankenski

Wishin I had a fat wife. 😬🤡😑

Frankenski profile image
Frankenski

Is the Daily Mail like the Daily Caller? I don't know who's who.

pjoshea13 profile image
pjoshea13 in reply to Frankenski

The Daily Mail is a British tabloid. The editor seems keen on reporting PCa news, but the coverage often makes me cringe.

-Patrick

Dan59 profile image
Dan59

Thank You Patrick , that is an incredible dissertation, I switched to Olive oil at the beginning. On a side note ,Do you know of anything that can reactivate PTEN in a Patient, I beleive this is one of the things that showed up on my Genetic testing.

Thanks for the paper, very well thought out and written!

Dan

pjoshea13 profile image
pjoshea13 in reply to Dan59

Dan,

The PTEN literature often uses terms such as "loss", "deletion" & "mutation", implying that restoration isn't possible.

However, epigenetic silencing is possible too, & this is reversible.

A 2009 Italian study [1]:

"... analyzed the expression of PTEN in presence or absence of azacitidine or valproic acid in a panel of 50 primary cultures derived from naive (UNT, 23 ptz) and bicalutamide-based neoadjuvant hormone therapy-treated patients (NHT, 27 pts)."

{Note: "Azacitidine can be used in vitro to remove methyl groups from DNA" [2].

Silencing of tumor suppressor gene via methylation of the promoter regions is common in PCa.

A natural demethylation agent is genistein. High dosage is required IMO.}

{Note: valproic acid is a histone deacetylase-inhibitor [3].

Epigenetic silencing can also be due to HDAC [histone deacetylase] which prevents the relevant DNA areas from being unwound & acted on.

Valproic acid is an old drug used against epilepsy. It could be repurposed.}

"Treatment with azacitidine increased the percentage of PTEN-positive cultures up to 72 and 80% for PTEN protein and mRNA determination, respectively. Treatment with valproic acid was able to increase the percentage of PTEN-positive cultures up to 80 and 74% for PTEN protein and mRNA determination, respectively."

So perhaps PTEN can be resuscitated?

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/197...

[2] en.wikipedia.org/wiki/Azaci...

[3] en.wikipedia.org/wiki/Valpr...

Dan59 profile image
Dan59 in reply to pjoshea13

Patrick, Thank You for looking into this, I really appreciate it.

Dan

Captain_Dave profile image
Captain_Dave in reply to Dan59

Broccoli (sulforaphane) is supposed to help PTEN deficient cells.

Link: sciencedaily.com/releases/2...

-Dave

Dan59 profile image
Dan59 in reply to Captain_Dave

Thanks for that paper Captain Dave, I will def be having some organic broccoli tonight.

pjoshea13 profile image
pjoshea13 in reply to Dan59

Dan & Dave,

"It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing), which allows the two compounds to mix and react." [1]

Unfortunately, heat destroys myrosinase, so cooking does not deliver active sulforaphane.

Cooked cruciferous vegetables can be rescued with a raw preparation of a cruciferous vegetable - e.g. pureed horseradish or wasabi.

Most sulforaphane products are Sulforaphane Glucosinolate & are usless. After many complaints, Jarrow added myrosinase to BroccoMax [2].

-Patrick

[1] en.wikipedia.org/wiki/Sulfo...

[2] swansonvitamins.com/jarrow-...

Dan59 profile image
Dan59 in reply to pjoshea13

Patrick, thank you, I ordered broccomax just now. Will eat some raw broccoli too.

Dan

Roland632017 profile image
Roland632017

Hi Patrick and Kuanyin

It is amazing that both of you had such a wealth of information including the depth and details into fats/fatty acids and Mediterranean/American diets etc.

Again I am a simple lay person.

Awhile back Nalakrats has reported he done some studies/published regarding Chinese tea as well as baking soda and I can understand them as he explained,

In view of all your findings, their was a link that all researchers had missed.

This I want to state is drinking tea.

Coming to how cancer cells pH environment is Nalakrats has confirmed in his studies that they proliferate at pH 6.7 and below that levels as you mentioned all the acids/fatty etc these environments will surely cause the cancer cells to keep dividing and multiply.

Now my hypothesis is and I managed to tie the link to all this natural cures since the early 1900. Look at Caisse founder of Essiac tea, even Dr Leonard Coldwell when he mentioned he cure her sick mum when he was a 14 year old boy.

I am delighted to point to you about this link and it is incredible.

Coming to tea and I bought 1 box Jasmine Green Tea ( 20x40g ) for $1.69 and when each tea bag brew it has a pH >8.0

I described to you about the critical bottle neck that you missed out when you highlighted Vernon Johnstone curing PCa using baking soda/molasses.

Again the interesting fact and crucial/critical aspect of that particular treatment was to maintain pH 7.2-7.5 and then boost up to 8.0-8.5 for 5 days and not beyond.

Hence any variation whether using tea/abscorbic acid (vitamin C/Laetrile (Vitamin B17/baking soda is sufficient and effective as well as some of this natural/synthetic derivatives had cancer killing properties which has been proven time after time.

So I take credit in pin point this accurate/informative post.

If I do get cure/manage my cancer's progress with a tremendous reduction/result I will award myself a Honorary Doctorate???? LOL

Thanks for putting up with my impertinence and for being patience.

This is my story.

Roland

Wish I could understand all this, too fat or not too fat. That is the question.

Side note:

When I decided to stop working I bought a 10 acre plot in the heart of farmland in Michigan. I'm surrounded by farmers/ranchers. You don't want to know what they put in the soil to grow soy and corn to feed the cattle. If that's not bad enough, the feed lots used prior to slaughter are something out of a madman's scientific lab. These cattle explode in size due whatever it is that they feed them. Believe me when I tell you feed lot food isn't healthy. It isn't grass.

Of course what do I know.

pjoshea13 profile image
pjoshea13 in reply to

It makes the cattle ill. Ruminal acidosis due to grain overload:

hindawi.com/journals/tswj/2...

-Patrick

Frankenski profile image
Frankenski in reply to

"Of course..." I love that.

MrEd44 profile image
MrEd44

Thank you for your research and effort. This makes sense to me, its more complicated than just fat and type of fat matters.

homer13 profile image
homer13

Pjoshea,

Thanks for the summary. I am (was) a patient of Dr. Myers and generally follow the idea except I am not sure how much of the approved oils (olive, avocado, hazelnut) to consume. I was a little unclear about your statement below. Is it good for flexibility vs rigidity and where does this leave olive oil with oleic acid?

Thx

But let's make the smallest of modifications - dehydrogenate at the halfway point. That turns it into an omega-9 monounsaturated fatty acid. Instead of being rigid, it bends in the middle. The result is oleic acid, the major fat in olive oil. The supremely healthy fat, according to some.

pjoshea13 profile image
pjoshea13 in reply to homer13

Homer,

Our ancestors were hunter-gatherers & our bodies handle the fatty acids found in animal fats & nuts pretty well. The stigma attached to the fats that have rigid molecules is based on the simple-minded idea that they must surely clog the arteries.

{The problem with meat might be more related to the cooking method than the fat.}

Our experience with bottled oils is relatively recent. Olive oil is an exception for only part of the world.

I don't believe that oleic acid is inherently healthy, but I do believe that a 40% fat diet is metabolically much healthier than a 10% or 20% fat diet. I also think that it is probably better to eat fatty foods such as olives, avocados & hazlenuts, than to use their oils.

With the Mediterranean diet, it isn't necessary to find ways to get a lot of fat into each meal - it's more about unlearning the modern aversion to fat. Fish is generally a healthy option (unless in batter & fried in canola oil, say), but why do people go for white flesh that is virtually fat free & with little flavor? Why is it so difficult to find herring & mackerel?

Many home cooks now avoid whole chickens, believing that only the breast is healthy eating.

In many traditional recipes, a sauce was a major fat contributor. A big no-no to many these days.

I don't count calories & I don't aim for precision in my 40% fat meals. The best advice I can give is to get an authentic Mediterranean cookbook, where the recipes are not fat-reduced for American tastes.

-Patrick

in reply to pjoshea13

Well put Patrick.

j-o-h-n profile image
j-o-h-n

So there's an old bull and a young bull on top of a hill with a bunch of cows at the bottom of the hill.

The young bull says to the old bull "why don't we run down the hill and knock one off?"

The old bull says to the young bull "why don't we walk down and knock them all off?"

Good Luck and Good Health.

j-o-h-n Thursday 01/18/2018 11:43 AM EST

p.s. I only eat meat on days that end in Y.

Roland632017 profile image
Roland632017

Hi yycandy

I am still wondering about you as no details.

Your kind words like other well intentioned fellow members in this forum is noted.

Today I am heading for CT & Bone Scan I by tomorrow I will know how my treatment for the last 2 weeks evolve.

My previous engagement with an oncologist which was supposed to be 15 January 18 was being rescheduled to 22 January 18 as I would want the new Scans.

We shall see.

Roland

Roland632017 profile image
Roland632017

Hi yycandy

Very much appreciating your feed back to my curiosity.

I hope you will continue to do and continue with this excellent progress,

Roland

Well put Nalakrats.

An M-14 bored out to use match rounds was one of the best sniper rifles ever used. Deadly accurate from a click out.

BigRich profile image
BigRich

Patrick,

Thank you for your common sense.

Rich

Twoofus profile image
Twoofus

Wow.

This is a rather elaborate discussion on which foods to include in our diets. Where did all these marvelous appetites come from?

I don’t even bother to consider eating a bowl of kale chips when it is a major victory for me to consume a bowl of ice cream.

Captain_Dave profile image
Captain_Dave

With all the talk about fat, that reminds me of one of my favorite supplements Boswellia (as in the supplement named 5 LOXIN). One of the articles that seemed to leave a big impression on me was a Life Extension article about the fat cascade to 5-lipoxygenase and 5-HETE. Here is the article:

lifeextension.com/Magazine/...

--Dave

pjoshea13 profile image
pjoshea13 in reply to Captain_Dave

Dave,

The starting point is linoleic acid [LA] - the omega-6 found in corn oil. It's a fat we should severely limit, & yet we are often advised to use polyunsaturated fats that have significant LA.

LA converts to arachidonic acid [AA] which is the omega-6 that we do not want in our PCa cells.

When NF-kappaB is activated, LOX & COX enzymes are created. They act on AA to produce the bad inflammatory metabolites.

We can limit AA uptake by having marine omega-3 EPA/DHA in the diet. However, we still need to inhibit NF-kB. But I use 5-LOXIN too.

-Patrick

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