Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone Sensitive Prostate Cancer Treated With Androgen Deprivation With O

[snoraste]

Just saw this article. I don't think it says anything that we don't know already, i.e., more aggressive combination therapies are significantly better than ADT alone for the advanced disease.

However, I found myself looking back at the original CHAARTED results, and their OS projection in particular. Let me just make it clear that I'm not obsessing over the OS numbers by any means - they're - among other issues -outdated and backward looking. But a question that I have is this: did the study keep the patients only on ADT or ADT+Docetaxel throughout all the way to the OS event despite progression? I can't see any information on additional treatments - just curious how this number is calculated.

[ctarleton]

I think Overall Survival in the earlier ADT vs. ADT+Docetaxel Trial was defined as "the time until death from any cause".

I think that subsequent treatments were also allowed (for obvious ethical reasons).

See also:

nejm.org/doi/full/10.1056/N...

And for documented Subsequent Treatments, see Table S3 in the Supplementary Appendix, here:

nejm.org/doi/suppl/10.1056/...

Charles

[snoraste in reply to ctarleton]

Thanks Charles - I see the info in the Appendix