Nilutamide

Sartor switched me to Nilandron/Nalutamide 150mg daily when casodex caused liver numbers to go out of range, it worked well for me in the adt program of zolodex and avodart at the time. It is a prescription medicine and I just got it at the local pharmacy.

My oncologist put me on nilandron after failing casodex. For me it was very expensive and completely ineffective. But we do respond differently to different meds.

Hi Taylor,

I had surgery and IMRT in 2009. The PCa recurred in 2011, so I went on ADT (Lupron, Casodex, Avodart and Cabergoline) and PSA dropped to undetectable. The Casodex quit working in 2014 (my PSA started rising). I switched to Nilutamide (150mg) and in 3 months my PSA returned to undetectable. In 2016, I reduced the Nilutamide dosage to 75mg daily. I stopped Lupron over a year ago, but remain on the other ADT oral drugs (plus Metformin 500mg) in 2016). Current PSA is undetectable and Testosterone is 40. I have never been on Degarelix or Zytiga.

Yes, from my medical oncologist.

I think there 7 lutamide drugs., minimal side effects. I'd give them a try, if one fails than the other monitoring psa monthlly till a durable response. Rocco

Hubby on Casodex monotherapy 150 mg/day. Curious to know why you stopped it due to possible resistance. Could you elaborate? Thanks!

I have been switched to Nilutamide (Nilandron),from Bicalutamide (Casodex)

for the same reasoning of my Oncologist,as well and after about two and half month of taking it, caused me Pneumonitis.

It was diagnosed, unfortunately, as bacterial ,non specific Pneumonia

and I almost dyed. I was loaded with many antibiotics,was on Oxygen

for 2 months,was given Corticosteroids and

Nilutamide was withdrawn. Than finally I was getting better after loosing 20 Kg (about 44 pounds ) in 2 months.

I am professional Chemist,

so later I was researching what was going on. One of Nilutamide rare side effects, in about 2-4 % of patients may cause "Interstitial Pneumonitis",

pneumonia like condition. It is described in the medical literature,but you have to specifically look for it. none of my attending physicians was aware of it !

Here is one of the links:

Nilutamide, Pneumonitis

and report on eight patients:

thorax.bmj.com/content/thor...

Both Bicalutamide and Nilutamide affect liver functions, even Bicalutamide was reported that it may rarely cause Pneumonitis :

Int J Clin Oncol. 2011 Dec;16(6):763-5. doi: 10.1007/s10147-011-0239-x. Epub 2011 May 3.

Interstitial pneumonitis induced by bicalutamide given for prostate cancer.

Masago T1, Watanabe T, Nemoto R, Motoda K.

I am no longer taking Nilatamide or Bicalutamide ,have appointments with specialists to see what will be the alternative.

I do not know if the link to my membership will show up:

its: Victorq1 and my e-mail is : winstonvictorn@gmail.com

if you like to get more information.