I am on the new protocol for PCa: Lupron w Zytiga. A friend suggested that I add milk thistle to enhance liver protection as these drugs can effect liver function. After two days adding this to my regimen I thought to call the pharmacist where my oncologist practices (Seattle Cancer Care Alliance). Word back: milk thistle might inhibit the metabolism of abiraterone, meaning it could lead to an increased concentration of the drug in my system, putting me at risk for more or increased side effects. Suffice it to say, I have stopped the milk thistle. Latest PSA: Lowest since I was diagnosed in 2005 @0.0- I can only hope this continues into the future.