Advanced Prostate Cancer
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Trigger Finger, Finger Joint Pain Analysis

About a month plus ago I asked for men who were experiencing that in the title to respond to me. I received exactly 30 responses, 28 had details, of drug use. 2 respondents had nothing to note, just that they had the malady.

Having been suspicious in my case, that having had an X-ray by my GP, one by my Orthopedic Hand Surgeon, and an MRI---which all showed perfect hands, and fingers. A CT Scan might have shown a shortening of the tendons or ligaments, but I did not go there.

Instead, I opted for a C-Reactive Protein Test to prove I had abnormal Inflammation, as pain normally would show some inflammation. Well my C-Reactive Protein came back abnormal. It showed Undetectable. And none of my Docs. ever saw an undetectable. Well I figured it was due to certain supplements I am taking, but cannot prove it.

So to go forth with a thesis that this Malady was drug induced, I asked for men to participate in this survey.

Results: 30 responses: 2 eliminated for lack of info. of the 28 men who provided drug information, 10 where both on ADT and Metformin, and the other 18 only indicated ADT.

There was suspicion, that some of the men only on ADT with Trigger Finger, may have been on Metformin also, and did not count it. That was subjectively determined by reading how the men presented their information. Absolutely some were not on Metformin, they made that clear. No time study was analyzed, to determine how long it took from the beginning of the taking of the drugs, like in my situation, I started Metformin a year after starting ADT. A much larger sample would be required with definitive start dates from the respondents. Taking into account when each protocol was started, and to the best of their knowledge how long it took to define the finger pain.

So this study is not scientifically correct as to being able to statistically be able to calculate % significance data, regarding use of the drugs. But we can make some intuitive conclusions.

Conclusion: That men either on ADT alone, but more surely with the addition of Metformin, have an unknown % of probability to acquiring this Malady. It is understood, theoretically, that age probably would have to be a consideration. Best proposal would seem to indicate the older you are there is a greater likelihood, with use of these drugs.

The incongruity of the lack of inflammation in my case, is a mystery.

Alan Meyer made a valuable contribution as to the use of using squeeze balls, and hand grippers, usually used to build hand strength, as a plausible cure. I have added hand exercise, and I am seeing some minor positive improvement.

Another improvement is coming from a new Supplement, I have added., called ROOT2, BioCell Collagen, Which you can get at Vitacost--It appears it is made for them by Life Extension and contains: Proprietary Chicken Sternal Cartilage Extract, Hydrolyzed Collagen Type 2, Chondroitin Sulfate, and Hyaluronic Acid. From my perch, a real advancement in joint, tendon and ligament supplementation.

Anyway this concludes my investigation. I will for myself, continue the Alan Meyer protocol, and the ROOT2. Hope there was value above.


8 Replies

For others with the problem:

I was doing about 1,000 squeezes per day with each hand (100-200 squeezes at a time) using one of those steel spring hand squeezers. Often, when not doing anything else with my hands, I squeeze them into fists and open them again with isometric resistance of the close and open muscles for the fingers, or do other finger exercises.

The other components are:

Use hot and cold water to rinse the hands when they're cramped or painful. That temporarily freed the cramping, pain, and trigger finger for me.

Sleep with the hands closed in fists. That reduced the incidence of waking up with stiff hands.

Incidentally, I looked up the drug label for one of the Lupron preparations and it said up to 33% of men taking Lupron long term (I don't remember the actual time period) will experience "joint pain".




I had trigger finger. I could not make a closed fist. The surgeon said without surgery I would not be able to close my fist. I did not have surgery, and instead squeezed my rubber ball and tried to close my fists. Eight months later I could to make a fist.



I also mostly recovered from this. At first, i had trigger finger in 4 or 5 fingers. It was super painful when i woke up in the morning. Now, a year later, i have just some slight stiffness in the morning, but no trigger and i can close my fists. So maybe my body was just reacting to the hormone changes at the beginning? I didn't really do anything about it, no surgery, no special exercises. It just seemed to slowly get better.


Interesting Info



Came across this thread looking for causes to my own increasing finger joint pains. I was first diagnosed with PCa in 2005 and started Lupron at that time (no surgery as disease was already outside the prostate). Intermittent HDT worked fine for control for years (and no joint pains). Had radiation in 2008, chemo in 2014, and went of Zytiga fom 2014 thru early this year (no joint pain throughout). Early in 2017 I had the full run of Xofigo radium injections (no joint pains). In April, I was transitioned from Zytiga to Xtandi (with continuous Lupron now, no holidays for several years). Within a month of starting Xtandi the joint pains commenced. FYI, I've also taken metformin for several years with no joint effects until now.

The one variable in my drug treatment that changed roughly in tandem with the onset of finger joint pain was Xtandi. Not conclusive, but certainly an interesting correlation.

Joint pain started with the outermost joint of the index finger on my right (dominant) hand, so painful that I bought a splint to immobilize it. I thought it might be gout, but no swelling or other symptoms except pain. Now all the fingers are beginning to show signs of the same pain, although luckily no 'trigger finger' symptoms have appeared.

I'll give the tennis ball squeezing a try for some relief. Thanks for the good info here.



My Rheumatoid Doctor said no squeezing--it will make it worse. I have dad a few sessions of Dry Needling--like acupuncture, but the needles go to the ligament and tendon wheels and pulley's that are stuck, from Androgen Deprivation---all scans are negative as well as x-rays---for Arthritis. I was given an exercise plan that works somewhat by a P. Therapist---but hard to describe here---it stretches the tendons and ligaments, to loosen them up. We have found some points in the upper palm, near the beginning of the fingers that are tiny nodules/stuck pulley's--and I am going to try 2 injections, at those points in 3 weeks--if this works we will do the rest of the fingers.

But the betting is--stop the drugs and the fingers get better/reversal, but then we might die. So we might have to live with it, for now.



Seems sometimes that all cancer treatment is a toxic Faustian bargain, doesn’t it?


Using Faust is pretty dark---You think?




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