Hi, been suffering on and off with depression for years now. Seem to have been on every antidepressant known and they work for a while then stop. I also have m.e which isn't helping and wad diagnosed with bi polar when I went manic a couple of times in the past. Don't feel anything like that anymore but scared to go out the house now . Life seems really pointless. The only thing that keeps me going are my pet rats that I love to pieces. Does anyone have any suggestions for new antidepressants that have worked for them, it feels like there's nothing left to help me.