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Deal on PROTACs: ARV-766 development will be carried out by Novartis
in a nutshell, a PROTAC (PROteolysis TArgeting Chimera) is like a specialized tool designed to eliminate unwanted proteins in the body. It's like a magic marker that marks a specific protein inside a cell (cancer cell in our case). This tricks the internal "waste management system" of into breaking down
in a nutshell, a PROTAC (PROteolysis TArgeting Chimera) is like a specialized tool designed to eliminate unwanted proteins in the body. It's like a magic marker that marks a specific protein inside a cell (cancer cell in our case). This tricks the internal "waste management system" of into breaking down
Maxone73
in
Advanced Prostate Cancer
2 months ago
Cholesterol test results?
Hi just got a call from my GP about the above test and,was advised to alter my diet -Serum cholesterol level 5.6 mmol/L Serum HDL cholesterol level 1.0 mmol/L Serum cholesterol/HDL ratio 5.6 [0.0 - 5.0]; Outside reference range Serum non high density lipoprotein cholesterol level 4.6 mmol/L Should
Hi just got a call from my GP about the above test and,was advised to alter my diet -Serum cholesterol level 5.6 mmol/L Serum HDL cholesterol level 1.0 mmol/L Serum cholesterol/HDL ratio 5.6 [0.0 - 5.0]; Outside reference range Serum non high density lipoprotein cholesterol level 4.6 mmol/L Should
Bigsi
in
Weight Loss Support
2 months ago
Ttck1825
I had a liver transplant in 2016 now last few years health isn't going great, and Dr wants to change my adoport to envarus, but my story is long. But just for now does envarus stop bad headaches, cause weight gain. Plus suffer low sodium levels and type 3c diabetic. That's me for now
I had a liver transplant in 2016 now last few years health isn't going great, and Dr wants to change my adoport to envarus, but my story is long. But just for now does envarus stop bad headaches, cause weight gain. Plus suffer low sodium levels and type 3c diabetic. That's me for now
Ttck1825
in
British Liver Trust
2 months ago
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hashimotos/4hr insulin intolerance
hi all as previous post just started 50mch levo , had a insulin intolerance test today as day case that should of been done in feb 24 but endocrinology doctor didn’t send prescription over to day ward . Finally took test today which had to be stopped half way through as my blood sugar went so low .
hi all as previous post just started 50mch levo , had a insulin intolerance test today as day case that should of been done in feb 24 but endocrinology doctor didn’t send prescription over to day ward . Finally took test today which had to be stopped half way through as my blood sugar went so low .
Jemjet
in
Thyroid UK
2 months ago
Worrying blood test results ...
Hello, This is my first post - last week I noticed some quite dark patches under both arms. Was seen by GP in an hour ... gave me Clotrimazole Cream which has reduced the tone of my skin. GP said it was acanthosis nigricans... ,?? Sent me for bloods including LFT and various tests FBC. These came
Hello, This is my first post - last week I noticed some quite dark patches under both arms. Was seen by GP in an hour ... gave me Clotrimazole Cream which has reduced the tone of my skin. GP said it was acanthosis nigricans... ,?? Sent me for bloods including LFT and various tests FBC. These came
Apollo14lmp
in
British Liver Trust
2 months ago
The 'Brain Energy Gap' and its possible implication on the progress of PD.
Has anyone else seen the work of Professor Stephen Cunnane on the 'brain energy gap' and its implications for PD, Alzheimers and cognitive impairment? I've put a link to one of his talks below, but to summarise: - Cognitive impairment and brain health in PD, Alzheimers, is due in part to an 'brain
Has anyone else seen the work of Professor Stephen Cunnane on the 'brain energy gap' and its implications for PD, Alzheimers and cognitive impairment? I've put a link to one of his talks below, but to summarise: - Cognitive impairment and brain health in PD, Alzheimers, is due in part to an 'brain
Mezmerric
in
Cure Parkinson's
2 months ago
Change to diet
Plodding along for years with T2, first metformin but now insulin twice per day. Reasonably good diet, try to avoid added or high sugar, although carbs can be my downfall, mostly active, low alcohol consumption. Blood glucose readings fairly consistent, though slightly above target and keep nudging
Plodding along for years with T2, first metformin but now insulin twice per day. Reasonably good diet, try to avoid added or high sugar, although carbs can be my downfall, mostly active, low alcohol consumption. Blood glucose readings fairly consistent, though slightly above target and keep nudging
50568789
in
Diabetes Research & Wellness Foundation
2 months ago
Ambulatory B/P monitors
Hi guys, I've just noticed that there are ambulatory monitors being advertised for sale. Wouldn't it be great if they did what they claim to do ! A bit akin to the difference between testing your blood sugar level at home, which is a snap shot of that moment and an hba1c blood test which gives an
Hi guys, I've just noticed that there are ambulatory monitors being advertised for sale. Wouldn't it be great if they did what they claim to do ! A bit akin to the difference between testing your blood sugar level at home, which is a snap shot of that moment and an hba1c blood test which gives an
itsok
in
High Blood Pressure Support
2 months ago
indapamide / Tinnitus
Hello Peeps, I recently went up from 1.25mg indapamide daily (half 2.5mg pill esch day) to 1.5mg indapamide extended release. Fairly quickly I noticed a low volume pulsating humming sound at home, particularly in the evenings that sounded a bit like there was an engine running. I even asked neighbours
Hello Peeps, I recently went up from 1.25mg indapamide daily (half 2.5mg pill esch day) to 1.5mg indapamide extended release. Fairly quickly I noticed a low volume pulsating humming sound at home, particularly in the evenings that sounded a bit like there was an engine running. I even asked neighbours
Ropa511
in
High Blood Pressure Support
2 months ago
Ursodeoxycholic acid
Hi, I've been on urso 2000mg daily for 8 years now, but it seems to give me diarrhoea lately. Does anyone else have this trouble, also does it mean it has stopped working? Thank you for any help.
Hi, I've been on urso 2000mg daily for 8 years now, but it seems to give me diarrhoea lately. Does anyone else have this trouble, also does it mean it has stopped working? Thank you for any help.
Hidden
in
PBC Foundation
2 months ago
Insomnia and Felodipine ?
Hi everyoneI have been on Felodipine for several weeks now after trying many other drugs for BP. While I feel a lot better on these drugs my existing insomnia is now off the scale!. I am now averaging 3 or 4 hours a night and over the counter sleeping pills aren't helping much. My GP says she has ran
Hi everyoneI have been on Felodipine for several weeks now after trying many other drugs for BP. While I feel a lot better on these drugs my existing insomnia is now off the scale!. I am now averaging 3 or 4 hours a night and over the counter sleeping pills aren't helping much. My GP says she has ran
BobbyCollins
in
High Blood Pressure Support
2 months ago
Timing of co-careldopa
I've written to US NLM regarding the difference of advice given when taken the co-careldopa pill, as follows....Thank you for contacting the U.S. National Library of Medicine (NLM). The details of your message are listed below. You can expect to hear from us within 2 to 5 business days. For additional
I've written to US NLM regarding the difference of advice given when taken the co-careldopa pill, as follows....Thank you for contacting the U.S. National Library of Medicine (NLM). The details of your message are listed below. You can expect to hear from us within 2 to 5 business days. For additional
Allypally49
in
Cure Parkinson's
2 months ago
Myo-inositol increasing TSH?
Hello, wondering if anyone has experience of taking myo-inositol and any impact on their TSH please? I’ve been taking it for 4 months for PCOS, TSH was 1.1 just before I started and is now 4.8 (T3 and T4 within range). I read up on it before I started and the (limited) research indicated it could be
Hello, wondering if anyone has experience of taking myo-inositol and any impact on their TSH please? I’ve been taking it for 4 months for PCOS, TSH was 1.1 just before I started and is now 4.8 (T3 and T4 within range). I read up on it before I started and the (limited) research indicated it could be
mountaingoat83
in
Thyroid UK
2 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
2 months ago
Megaloblastic anaemia
Hi, I was diagnosed with megaloblastic anaemia yesterday. My gp, sent over a prescription for Cyanocobalamin 1mg/1ml solution for injection ampoules. My pharmacy and other pharmacies don't stock it. I left a note for my doctor with the receptionist to ask for possibly a different brand or type. I'm new
Hi, I was diagnosed with megaloblastic anaemia yesterday. My gp, sent over a prescription for Cyanocobalamin 1mg/1ml solution for injection ampoules. My pharmacy and other pharmacies don't stock it. I left a note for my doctor with the receptionist to ask for possibly a different brand or type. I'm new
fatfatfat
in
Pernicious Anaemia Society
2 months ago
promising delivery technique for cancer drugs
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
Maxone73
in
Advanced Prostate Cancer
2 months ago
Berberine and iron?
Hi, So glad to have found this wonderful forum! I am a 74 year female who recently started taking pregabalin for RLS. I just got back my ferritin level and it is 12. I will order some iron and would like to know how many mg is a good dose. Also, I started taking niacin 500mg daily for my cholesterol
Hi, So glad to have found this wonderful forum! I am a 74 year female who recently started taking pregabalin for RLS. I just got back my ferritin level and it is 12. I will order some iron and would like to know how many mg is a good dose. Also, I started taking niacin 500mg daily for my cholesterol
glorious-granny
in
Restless Legs Syndrome
2 months ago
Wednesday's 'Word'
[u][i]
Hepatocytes -
[/i][/u] These are simply the cells of the liver. Each of these cells performs all of the functions of the liver - there is no difference in what any of them do for us. Liver failure occurs when there are not enough functioning hepatocytes to do all the functions they are
[u][i]
Hepatocytes -
[/i][/u] These are simply the cells of the liver. Each of these cells performs all of the functions of the liver - there is no difference in what any of them do for us. Liver failure occurs when there are not enough functioning hepatocytes to do all the functions they are
DonnaBoll
Administrator
in
PBC Foundation
2 months ago
Indapamide
I have been on 10mg Amlodipine and 10mg Ramipril for some years now. My blood pressure has slight increased to 135/96. Due to the raised DBP, my doctors wants me to add Indapamide. Is anybody taking Indapamide? are there any side affects? Would be interested in hearging from anyone who is
I have been on 10mg Amlodipine and 10mg Ramipril for some years now. My blood pressure has slight increased to 135/96. Due to the raised DBP, my doctors wants me to add Indapamide. Is anybody taking Indapamide? are there any side affects? Would be interested in hearging from anyone who is
AnimalNatureLover
in
High Blood Pressure Support
3 months ago
Starting fresh - probiotics
Hello people. I recently became disillusioned with the supplements I was taking. It came about because I restarted berberine after a three month break. My normal brand, renew by science, have doubled their strength, and within a day or two I was finding I was ridiculously tired, like I'd run a marathon
Hello people. I recently became disillusioned with the supplements I was taking. It came about because I restarted berberine after a three month break. My normal brand, renew by science, have doubled their strength, and within a day or two I was finding I was ridiculously tired, like I'd run a marathon
Karmaone
in
Cure Parkinson's
3 months ago
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