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Olaparib/Durvalumab Combo Shows Promise in mCRPC
Olaparib/Durvalumab Combo Shows Promise in mCRPC http://www.onclive.com/conference-coverage/gu-2018/olaparibdurvalumab-combo-shows-promise-in-mcrpc Wayne Kuznar Published: Friday, Feb 09, 2018 The PARP inhibitor olaparib (
Lynparza
) appeared to complement the antitumor activity of the PD-L1 inhibitor
Olaparib/Durvalumab Combo Shows Promise in mCRPC http://www.onclive.com/conference-coverage/gu-2018/olaparibdurvalumab-combo-shows-promise-in-mcrpc Wayne Kuznar Published: Friday, Feb 09, 2018 The PARP inhibitor olaparib (
Lynparza
) appeared to complement the antitumor activity of the PD-L1 inhibitor
JLS1
in
Advanced Prostate Cancer
6 years ago
Lynparza
Am starting
Lynparza
next week. Any one else taking it?
Am starting
Lynparza
next week. Any one else taking it?
Lombardi24
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
Olaparib [
Lynparza
] has had success in men with hereditary BRCA1 or BRCA2 mutations. As wonderful as newer drugs such as Zytiga are, resistance can lead to the emergence of cells that are very difficult to manage.
Olaparib [
Lynparza
] has had success in men with hereditary BRCA1 or BRCA2 mutations. As wonderful as newer drugs such as Zytiga are, resistance can lead to the emergence of cells that are very difficult to manage.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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Lynparsa
My new treatment for prostate cancer will be provenge and
lynparza
. Got a call from Express Scripts that they don't cover
lynparza
for prostate cancer. Will talk to my oncologist on Monday to appeal this decision. Has anyone had this problem?
My new treatment for prostate cancer will be provenge and
lynparza
. Got a call from Express Scripts that they don't cover
lynparza
for prostate cancer. Will talk to my oncologist on Monday to appeal this decision. Has anyone had this problem?
hysir
in
Advanced Prostate Cancer
7 years ago
Update - CT scan today, continuing Olaparib and 30 days in, of cannabis oil!
My current status (Jan 2017) is that the Olaparib/
Lynparza
is likely not working for me. My count & symptoms have continued to increase. Next step is likely Chemo in March I think... well that’s the oncologists plan anyway.
My current status (Jan 2017) is that the Olaparib/
Lynparza
is likely not working for me. My count & symptoms have continued to increase. Next step is likely Chemo in March I think... well that’s the oncologists plan anyway.
SarahsJourney
in
My Ovacome
6 years ago
Lynparza
Anyone out there on
lynparza
?
Anyone out there on
lynparza
?
Izmeg
in
My Ovacome
7 years ago
Olaparib/ lynparza insurance coverage
My doctor has prescribed Olaparib, and pills, and i’m shocked to learn that my copay under Medicare is > $2,240 for 120 pills. Are any of you taking this drug, recently approved for Non BRACA gene ovarian patients? If so, what is Your copay And under what insurance plan? Also , what is your experience
My doctor has prescribed Olaparib, and pills, and i’m shocked to learn that my copay under Medicare is > $2,240 for 120 pills. Are any of you taking this drug, recently approved for Non BRACA gene ovarian patients? If so, what is Your copay And under what insurance plan? Also , what is your experience
CJCM123
in
SHARE Ovarian Cancer Support
7 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
In a phase II study of olaparib (
Lynparza
), a PARP inhibitor, treating patients with metastatic CRPC and DNA repair defects, the drug was proven to lead to high response rates in this patient population.
In a phase II study of olaparib (
Lynparza
), a PARP inhibitor, treating patients with metastatic CRPC and DNA repair defects, the drug was proven to lead to high response rates in this patient population.
JLS1
in
Advanced Prostate Cancer
6 years ago
Post second line chemo check up - positive news
I have to decide whether I want to have my original tumour tested for the BRCA gene (it's not in my blood) which costs A$1200 - if I am positive it opens up the option of oliaparib (
lynparza
) as a maintenance therapy.
I have to decide whether I want to have my original tumour tested for the BRCA gene (it's not in my blood) which costs A$1200 - if I am positive it opens up the option of oliaparib (
lynparza
) as a maintenance therapy.
Hidden
in
My Ovacome
7 years ago
Lynparza (olaparib), a PARP inhibitor, before CRPC.
The idea seems to be that PARP, a defect repair mechanism, is increasingly called upon during ADT, so there might be synergy between ADT & a PARP inhibitor such as
Lynparza
, well before CRPC emerges. More cell death up-front & a longer mean time to CRPC?
The idea seems to be that PARP, a defect repair mechanism, is increasingly called upon during ADT, so there might be synergy between ADT & a PARP inhibitor such as
Lynparza
, well before CRPC emerges. More cell death up-front & a longer mean time to CRPC?
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Interesting CA125 readings
I am on daily
Lynparza
8 pills Twice a day and Avastin every three weeks since December. My CA125 at the start of this protocol was 150 after a 3 or 4 month I was down to 50. Needless to say I was happy.
I am on daily
Lynparza
8 pills Twice a day and Avastin every three weeks since December. My CA125 at the start of this protocol was 150 after a 3 or 4 month I was down to 50. Needless to say I was happy.
Hidden
in
SHARE Ovarian Cancer Support
7 years ago
Lynparza
My husband BRCA2 positive will begin treatment next week with
Lynparza
. Does anyone have experience taking this drug?
My husband BRCA2 positive will begin treatment next week with
Lynparza
. Does anyone have experience taking this drug?
Craigslife
in
Advanced Prostate Cancer
7 years ago
BRCA-2, etc, in CRPC.
Lynparza
(Olaparib) is a PARP inhibitor that has had some success in cases with BRCA1/2 & ATM repair gene defects From Steve Freedland: ... we conducted "prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals." "... aberrations
Lynparza
(Olaparib) is a PARP inhibitor that has had some success in cases with BRCA1/2 & ATM repair gene defects From Steve Freedland: ... we conducted "prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals." "... aberrations
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Chemo while low PSA
, Xofigo 2016 (mets in shoulder and ribs),
Lynparza
2016. The PSA never went over 10.5. I have been diagnosed with a BRCA2 mutation, which is the reason I started with
Lynparza
(Olaparib).
, Xofigo 2016 (mets in shoulder and ribs),
Lynparza
2016. The PSA never went over 10.5. I have been diagnosed with a BRCA2 mutation, which is the reason I started with
Lynparza
(Olaparib).
Terje
in
Advanced Prostate Cancer
7 years ago
Introduction
now taking
Lynparza
for 3 months.
now taking
Lynparza
for 3 months.
tcrobey
in
SHARE Ovarian Cancer Support
8 years ago
Starting Lynparza
I feel as if I am reaching the outer limits of "normal" treatment, but am excited to start it, as 80% of those on
Lynparza
achieve a complete remission. Has anyone else out there taken
Lynparza
, and if so, what side effects? Thanks.
I feel as if I am reaching the outer limits of "normal" treatment, but am excited to start it, as 80% of those on
Lynparza
achieve a complete remission. Has anyone else out there taken
Lynparza
, and if so, what side effects? Thanks.
vandy69
in
Advanced Prostate Cancer
8 years ago
Xtandi - Pfizer ... & some big numbers.
One such drug, AstraZeneca’s
Lynparza
, is already on the market and several more are in development. Tesaro recently announced positive data in ovarian cancer for its PARP inhibitor, raising the perceived value of other drugs of its type.
One such drug, AstraZeneca’s
Lynparza
, is already on the market and several more are in development. Tesaro recently announced positive data in ovarian cancer for its PARP inhibitor, raising the perceived value of other drugs of its type.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
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