Pregabalin Overload!: Just started a... - Restless Legs Syn...

Restless Legs Syndrome

22,262 members16,268 posts

Pregabalin Overload!

MumofSam profile image
6 Replies

Just started a new prescription of the above two days ago. I noticed I struggled to get up yesterday and felt a little “drugged” and today the feeling is even worse, with brain fog as well, and I just want to sleep. I remembered feeling like this for a while when I went back on Pregabalin, before it wore off. So, thought I’d take a look at at this new box of Pregabalin to see what was different about it.

Found the difference! The capsules are each 150mg and I’m supposed to be taking 50mg capsules, so instead of taking 100mg of Pregabalin a day I’ve been taking three times that dose for the last two days. No wonder I’ve been feeling like this! And no wonder I’ve not been bothered by RLS at all and have slept well.

I’ve got a new prescription at the pharmacy to pick up (I’m a prescription ahead as I already had some and reorder just as I’m about to start the last box) and I’m sure the pharmacy won’t have made the same mistake.

It’s confirmed for me that I definitely needed a higher dose of Pregabalin, though think 300mg a day might be too high?

Is anyone else on a high dose of Pregabalin? I know the sleepiness and brain fog would wear off, but do the RLS symptoms stay under control or creep back?

Written by
MumofSam profile image
MumofSam
To view profiles and participate in discussions please or .
Read more about...
6 Replies
Pindarinda profile image
Pindarinda

Hi MumofSam,For thee years i use 300 mg pregabaline 2 hours before bedtime, with permission to swallow 1 extra capsule of 50 mg in case the rls returns during the night. In my case the rls is well under controle. I seldom need to swallow the extra capsule of 50 mg. 300 mg is sufficient. Feeling sleepy disappeared within a week. I am a happy user the pregabaline!

Hi, yes have been on 300mg of pregabalin for several years. I find this dose keeps my PLMD at bay although do find the side effects problematic (tired during day, brain fog, memory problems etc). That said, I am grateful for the sleep I get on pregabalin.

martino profile image
martino

I take 300 mg twice a day in part to help with neuropathic pain. I do suffer with brain fog and have thought that a switch to buprenonorphine or methadone might help. I will have a chat to the neurologist about this

in reply tomartino

Hi Martino, just wishing to share my experience of trying to switch from pregabalin to opioids.I have tried buprenorphine, oxycodone/naloxone, codeine and Tramadol, all while taking pregabalin. I found I suffer quite an extreme response to the opioids, eg. insomnia, nausea etc. I have since read that pregabalin potentiates opioids meaning that it heightens the effects of opioids, both good and bad. So while I had written off opioids, I'm thinking that it may have been the combination of opioids with pregabalin that was the problem.

Next time I try opioids, I'll do it when I'm either off pregabalin or taking a very low dose.

dickJones profile image
dickJones

Lying awake after a single PLMD event lasted for 2 hours. Couldn't walk it off in 10/20 minutes as usual. And I've been on 450 mg for 1 year. So, yes, it can wear off eventually!

RLSofManyYears profile image
RLSofManyYears

Hi, I've been on 300mg for several years now. I was initially given it by the neurologist to help with the effects of augmentation (although I didn't know about augmentation then and I'm not sure he did either). I know that when I try to reduce the dosage then my symptoms get worse. I went on to Temgesic last November and it stopped my symptoms dead for several months. However they gradually returned and so I've currently moved back on to ropinirole for a short while (about a month I think) before switching back to Temgesic. Once the RLS/PLMD has settled down then I'm going to start reducing the Pregabalin by 25mg per week or two. I've already got what I need. I think it is a "see how it goes" scenario then main aim being to keep meds to a minimum whilst ensuring a decent nights sleep. The lack of sleep is just so debilitating.

Not what you're looking for?

You may also like...

Pregabalin Dose Timing

Hi, All. I had my first appointment with my new neurologist today. The only RLS medicine that...

RLS Targinact & Pregabalin

is anyone using Targinact and Pregabalin for RLS and what strength? I am taking 15 mg Targinact...
susiehandley profile image

Pregabalin

Hi all, back again with another question, I was taking gabapentin a few months ago which was...
Leelee49 profile image

Pregabalin

I have been on 600mg of Gaberpentin for at least two years for RLS and a couple of weeks ago I...
DisneS profile image

Pregabalin dosage

I take 75mg of pregabalin daily. I still get substantial Rls symptoms which I treat with Kratom....

Moderation team

Kaarina profile image
KaarinaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.