Confused on the criteria 2019

[purplesnowflake]

Hi. I have had UCTD for years (my bloods always fine despite symptoms) but my daughter in twenties has been having similar symptoms. She's Ana negative but showing positive in anti-dsdna and anti-dna Smith antibodies. Without the Ana does this mean they won't see it as lupus?

Thanks.

[Sara_A]

I think but don't quote me it's the anti dsdna which is the more important and more significant one??

[purplesnowflake in reply to Sara_A]

Thank you

[KayHimm]

The fact that the doctor ran the tests means they saw symptoms of possible autoimmune disease. I think it is very rare to have a negative ANA with positive specific lupus antibodies. I remember seeing this question posed to a rheumatologist by a GP once. He said it is theoretically not possible and probably a lab error with ANA. Definitely ask the rheumatologist for his explanation.

I would not be concerned. They look for a constellation of symptoms. The labs confirm what they already see clinically. They will take all seriously.

What are her symptoms?

Sorry your daughter is going through this.

Kay