Annovis Bio Buntanetap : With the... - Cure Parkinson's

Cure Parkinson's

26,491 members27,905 posts

Annovis Bio Buntanetap

JohnP65 profile image
28 Replies

With the Buntanetap phase III trial dosing ending soon, I noticed that Annovis Bio stock is dropping like a rock. It is at a 52 week low. This makes me wonder if results are being leaked, and they are not promising. I hope I am wrong, and this is not another sham, but I can’t help but think about Annovis and the failed AD drug trial. Same thing happened, the stock value dropped sharply.

Written by
JohnP65 profile image
JohnP65
To view profiles and participate in discussions please or .
28 Replies
park_bear profile image
park_bear

I believe they are in need of additional financing which is also a possible reason for the decline

PDTom profile image
PDTom in reply topark_bear

but if Buntanetap works and the phase 3 trial is successful, it should be no problem to get money from investors.

I personally put a lot of hope in this drug.

Unfortunately, there are not many promising phase 3 studies.

This year I also had the feeling that not much has happened in research (pharmaceutical industry).

Here a new Youtubevideo from me...

youtu.be/FCpj432ycKo

park_bear profile image
park_bear in reply toPDTom

Of course a good Phase 3 result would make all the difference in raising money. However, as it stands now they will run out of money by the end of the year. So if they're waiting for the result before raising $, analyzing the data will be a race against time, with dire consequences if the result is a disappointment.

With all that said, as pointed out below, the action in the biotech index fully explains the price action.

Rupa88 profile image
Rupa88 in reply toPDTom

wow, you are doing great🧿🧿🧿🧿🧿🧿🧿

Have you been in their trial?

Hiw long have you had PD?

PDTom profile image
PDTom in reply toRupa88

parkinsonclub.de/en

MBAnderson profile image
MBAnderson

prospective investors are reading anecdotes on this forum.

glanvill profile image
glanvill

The entire biotech sector is down at the moment. The relevant index (XBI) is almost as low as it was during the Covid panic. I don’t think there is much to read into it.

Pixelpixie profile image
Pixelpixie

I’m in the Trial and have seen no benefits but maybe I’m on a placebo or too low a dose. Hard to know

gaga1958 profile image
gaga1958 in reply toPixelpixie

me 2

jimcaster profile image
jimcaster in reply toPixelpixie

Me too

Btraveria1 profile image
Btraveria1

I’m in the trial and have seen significant improvements

ProudParkie2017 profile image
ProudParkie2017 in reply toBtraveria1

I did too! I have been off since July and definitely see a difference. I am really hoping for open label extension!!

Btraveria1 profile image
Btraveria1 in reply toProudParkie2017

So am I. I’m afraid to go off!

Pixelpixie profile image
Pixelpixie in reply toBtraveria1

What improved?

Btraveria1 profile image
Btraveria1 in reply toPixelpixie

Not dragging Right foot anymore, almost normal R arm swing, some more sense of smell, I can handwrite again, less R shoulder pain and some less tremor (unless under stress)

ProudParkie2017 profile image
ProudParkie2017 in reply toPixelpixie

my response is almost identical. Probably the most significant change for me was getting an arm swing back again after seven or eight years of not having one! I had less tremor and I had virtually no off times. My score dropped from an 18 to an 8. And 8 is what it was at diagnosis! I felt better, I had more energy and I was exercising. Now that I am off I am definitely having off times and I’m actually looking to add something to my medication’s to supplement. One odd factor for me… I am a younger woman with Parkinson’s (52). I had been in perimenopause and had not had a cycle for two years. I started having cycles the month after the trial started and had my last cycle right as the trial ended. 🤷‍♀️

Pixelpixie profile image
Pixelpixie in reply toProudParkie2017

so pleased for you. You might want to look into B1 therapy

Pixelpixie profile image
Pixelpixie in reply toProudParkie2017

What improved?

Ctime profile image
Ctime in reply toBtraveria1

I was in the trial. Objectively at the end of the trial my C/L does was reduced by my neuro. Now an appointment 3 months post study, I am under medicated. Subjectively my sense of smell improved. In 3 months since, bradykinesia has worsened, mood and anxiety have worsened.

I would definitely do an open label trial

Btraveria1 profile image
Btraveria1 in reply toCtime

wow.. fingers crossed , as they say, for the open label trial for all of us participants. I am still currently on the medication , as my site started late. I am not looking forward to running out and doing without.

gaga1958 profile image
gaga1958

i am in the trial also and have not seen any improvement or difference

111BANDIT profile image
111BANDIT

Bio tech in general has been dropping like a rock. It has more to do with the availability of capital and interest rates since most biotech don’t have positive cash flow. To raise operating cash they generally issue shares which dilutes the value of shares in the short term.

MarionP profile image
MarionP in reply to111BANDIT

True but if the product is a killer then that stock price is going to hold up much better than its peers because it will justify access to capital, and you will get this with the price indicator called "RP," which stands for relative performance. If rp is above 70 it's a good sign, and if it's above 80 it's a very good sign.

Rupa88 profile image
Rupa88

It was never promising to me

MarionP profile image
MarionP

Actually stock price action over time is not a bad indicator.

Delaraysbest profile image
Delaraysbest in reply toMarionP

Over 300,000 shares traded yesterday at the lowest price all year. So there are buyers out there. Thankfully.n

JohnP65 profile image
JohnP65 in reply toDelaraysbest

Apparently they had positive data for Buntanetap in an AD trial. Hopefully there will be positive results for PD too.

Delaraysbest profile image
Delaraysbest

They are planning a mid-November earnings release and update. Fingers crossed!

Not what you're looking for?

You may also like...

Annovis Bio - Buntanetap - the share price is down and I wonder why?

Annovis Bio - Buntanetap - the share price is down and I wonder why? There are conflicting...
PDTom profile image

Annovis Bio Announces Approval for EU Clinical Trial Sites for the Phase 3 Study of Buntanetap for the Treatment of Parkinson's Disease

This trial is already open in the United States, and I believe some on this forum are...
Canddy profile image

ANNOVIS BIO ANNOUNCES POSITIVE FDA FEEDBACK FOR BUNTANETAP PHASE 3 CLINICAL DEVELOPMENT IN PARKINSON'S DISEASE (ANVS401)

https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?releaseID=111474&d=20

Annovis Bio Announces First Patient Dosed in Phase 3 Trial in Patients with Early Parkinson’s Disease

Annovis Bio Announces First Patient Dosed in Phase 3 Trial in Patients with Early Parkinson’s...

Annovis Bio's Phase 3 trial of Buntanetap/Posiphen: Trial record has been updated (contacts and locations)

There are now 18 locations mentioned in the updated trial record (September 12, 2022): - one in...
jeffreyn profile image

Moderation team

See all
CPT_Aleksandra profile image
CPT_AleksandraAdministrator
CPT_Anaya profile image
CPT_AnayaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.