Are any of you taking vitamin B12 regularly, if so, which of the 4 main formulas are you taking.
This report has me interested in beginning a B12 supplement, I’m looking for help in choosing the right formula…someone much smarter than me will likely know, thanks in advance.
Interesting information. I work with a naturopath/pharmacist who has me talking B12-2000 twice a week. It also has B6 2mg, (pyridoxal-5-phosphate),and folate (as calcium pollinate 800mcg DFE.)
I’ve been taking the P5P for a few weeks now…do you know the specific B12 formula you’re taking ?
Just to add to this topic, I’ve been taking Magnesium Glycinate and definitely notice a difference in my overall mood, I was taking Magnesium Oxide, don’t bother with the oxide…it’s useless
Very interessting. may i ask, do you benefit from it? I once read that a person with parkinson completely recovered from b12 injections. How long have you been taking that? Thanks for sharing
I would recommend Methylcobalamin as it is natural versus Cyanocobalamin which is synthetic. Methylcobalamin contains a methyl group which provides detoxification support. Cyanocobalamin contains a cyanide molecule which is not enough to kill a person, but why put that into your body. The gold standard is injectable methylcobalamin but you would need a prescription and have a compounding pharmacy (sterile) compound it. Next best absorbed format is sublingual tablets. Ortho Molecular Products makes a 5000mcg methylcobalamin + 1000mcg folate sublingual tablet... for once a day use. Swallow tablets are not well absorbed and are typically not recommended.
' Vitamin B12 was not associated with lung cancer risk. In this sample of Chinese adults without confounding by unmetabolized folic acid, higher levels of 5-mTHF were associated with lower risk of incident lung cancer. '
Another consideration is that B12 deficiency can cause increased homocysteine and increased homocysteine can increase cancer risk as discussed here :
' One meta-analysis performed by Collin et al. demonstrated the relationship between blood total homocysteine and prostate cancer [21]. Another meta-analysis written by Xu et al. found that higher blood homocysteine levels increased gastric cancer risk [22]. '
A conundrum indeed. In any case you could conclude that it is wise to test your homocysteine level regular and recommended for a good interpretation to determine also vitamin B6, vitamin B12 and folic acid. Supplement only if really necessary.
I have the LRRK2 gene that makes it very likely I will develop PD if I live long enough. I was impressed by a study published in 2019 that showed in various animal models that the adenosyl form of B12 - adenosylcobalamin - inhibits the LRRK2 overactivity that is responsible for some genetic and some sporadic forms of PD.
I take 1 milligram of sublingual adenosyl cobalamin once or twice a week - the strawberry flavoured tablet contains 1000mcg (micrograms). I probably should take it more often. I believe absorption is much better from the mouth than swallowed - you place the tiny round tablet either under the tongue or tucked up between your teeth and cheek under the upper lip on either right or left side.
I don't think the study from Singapore about tiny differences in dietary B12 being correlated with higher rates of lung cancer is relevant - larger B12 intakes from diet would correlate with lots of confounders like higher red meat/eggs/animal protein and animal fat intake that could be the causal factor.
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