Bendamustine

[dickcll]

Hi

Male from 1946.

Diagnosed for CLL in 1995.

2013 : Leukeran + Rituximab

In 2021 I received only 1 cycle of Bendamustine (90) + Rituximab.

No further cycles because of hemolyse.

2024 Now possibly Venetoclax + ? Appointment with oncologist next friday.

Not much of a help.

Best regards,

Dick

[AussieNeil Partner Founder Admin]

Hi Dick,

Am I correct in assuming you are wondering how your one cycle of Bendamustine + Rituximab (BR) might influence the effectiveness of your next treatment? People treated with older drugs like Bendamustine have been shown to have a higher incidence of del 17p and mutated TP53 chromosomal damage in their CLL. (The TP53 gene is located on chromosome 17, so is usually lost with 17p del CLL.) If that genetic damage becomes present, it means re-treatment with Bendamustine or older drugs reliant on functional TP53 is much less effective.

You only had one cycle of BR, so are less likely to have 17p del or mutated TP53. Your oncologist has also probably done FISH testing to check if you have 17p del, so ask! Targeted therapies, such as venetoclax, rely on other means than having a functional TP53 gene to kill CLL cells, so your treatment with venetoclax should work well. Venetoclax is commonly paired with obinutuzumab, a second generation and more effective version of rituximab, or a Bruton's Tyrosine Kinase inhibitor, such as acalabrutinib, ibrutinib or zanubrutinib, all of which aren't reliant on having a functional TP53.

Neil

[dickcll in reply to AussieNeil]

Hi Neil,

Thanks a lot.

Your info will help me with the next step.

Best regards

[LeoPa]

Wow, 19 years only on those 2 treatments. You did really well.

[dickcll in reply to LeoPa]

WOW indeed. Thanks

Btw, 29 years is more accurate 😎.

I am extremely lucky.

Have a good life.

[LeoPa in reply to dickcll]

Oops, Time is flying real fast😁.

[Skyshark]

Relapsed in the Netherlands 2nd line after CIT (benda) is Venetoclax + Rituximab.

pure.rug.nl/ws/files/253899...

HOVON 2nd line

[dickcll in reply to Skyshark]

Thanks Skyshark,

Very helpfull info for my fridayconsult.

Best regards,

Dick