Is a Liquid biopsy of ctDNA with PSA ... - Advanced Prostate...

Advanced Prostate Cancer

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Is a Liquid biopsy of ctDNA with PSA = 6 and 4 bone mets, useful?

Manilo profile image
8 Replies

Hello friends

I have to pay upfront the costs but I don't know if nothing will be found in a liquid biopsy with PSA of 6.5

What is your experience with liquid biopsy?

And did anyone have a bone metastatic solid biopsy ?

Thank you 🤗🙌

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Manilo profile image
Manilo
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8 Replies
Tall_Allen profile image
Tall_Allen

Are the bone metastases big enough to biopsy? Most genomic tests give unactionable results.

Manilo profile image
Manilo in reply toTall_Allen

Everybody says bone tissue is not usefull for DNA testing.

Tall_Allen profile image
Tall_Allen in reply toManilo

Who is "everybody"? I've never heard that and several patients I know have had it.

Manilo profile image
Manilo in reply toTall_Allen

My oncologist, urologist and RO

Tall_Allen profile image
Tall_Allen in reply toManilo

That's exactly what somatic genomic tests do. Perhaps they meant that your lesions were too small to biopsy.

tango65 profile image
tango65

Probably no. The circulating DNA or RNA yield is usually low with few bone mets and PSA below 10.

NanoMRI profile image
NanoMRI

Regarding health coverage, several times my appeals of initial private insurance denials here in US resulted in coverage; I had successes with this in UK as well. (US Medicare did cover my GUARDANT360 - at usSPA of 0.03 and no known bone mets).

As to the value of the test for you, I suggest asking your doctor what a result of 'Not Detected' would mean to your diagnosis and treatment strategy. And also, how might a detected findings alter these?

Others disagreed with there being value to my testing - these can be found in my recent post "Experiences with GUARDANT360 liquid biopsy" (23 days ago). Just a few days ago I met with a new to me medical oncology & hematology MD to discuss my hemochromatosis, and I asked for his opinion on my having had the GUARDANT360. He was very supportive and also saw great value in the "Not Detected' findings.

Aldo62 profile image
Aldo62

I got a blood biopsy and it told me that I was not genetically predisposed to getting Prostate cancer. In the end, it didn't make a lot of difference to my treatment plan, but it's useful info for my kids, both of whom are young men now.

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