Any experience with Selegilene?

[Anchor1]

Three years post diagnosis, my neurologist wants me to try Selegilene.

[park_bear]

Helps a bit. No adverse effects experienced.

[nednedned]

healthunlocked.com/cure-par...

healthunlocked.com/cure-par...

[Zella23]

after 4 years on C/L my husband had Rasagaline a similar drug to Selegiline an MAO b inhibitor. It allowed him to keep dopamine drugs at the same level. Still taking it after 9 years.

Recently tapered it down then stopped it for 3 weeks, slowed down quite a bit. Started to slowly retake, it definitely makes a difference to him. But we all react differently to drugs.

[Fricnfrac1999 in reply to Zella23]

Rasagiline did not help my husband. But neither did Entacapone or Opicapone.... Still waiting on that miracle drug .

[JH23]

Just about to start Rasagiline so was going to ask the same question

[cjCardio53 in reply to JH23]

Me, too. (for freezing and poor gait) Let me know how it goes.

[MarionP]

Pretty common, by now, MAO-B inhibitor. Intended to increase and extend the effects of levodopa. Pretty generally well tolerated but like any other drug, you try it and see.

[Mandoblast]

S is an earlier version of R. One of its metabolites is Methamphetamine. Doc thought it might give me a boost. I tried Seg in place of Ras for a month. I did feel a bit of a push.. But the constipation was prohibitive. HIs words: " I wonder if you would be one of the patients that do well on Seg...." I guess I wasn't, but still glad he sees the value in trying things.

[HugoRipanykhazov]

I started out on Selegilene and sinemet but stopped the selegilene after a slightly lengthy period 'cos it didnt seem to be doing anything with my very light and very slowly advancing PD. A brain surgeon friend of mine said it was a discredited drug that no one really used much any more.

As I understood it at the time, there had been a suggestion that it could arrest the symptoms of PD.

Ha Ha.

[bassofspades]

I was on it for a little while. I dont want to get into details, but it was a horrible experience for me.

[Farooqji]

It worked for me in the beginning of the disease. Still taking it but have not been so effective. It may reinforce levodopa

[Farooqji]

There was a belief some time ago that selegiline may slow down the progression

[PalmSprings]

I have found like some others that it extends the life of the c/l. I stopped taking it for a significant period of time thinking it didn’t do much but then realized that I wasn’t feeling as well. I renewed my prescription and feel it adds to my occasional feeling of wellbeing. But only in conjunction with the c/l because I went the other way with Rasagiline only and I felt virtually no relief.