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PNT article on recent success in generating locus coeruleus (LC) norepinephrine (NE) neurons, to study their role in diseases such as PD.
"Nerve cells originating in the locus coeruleus extend throughout the brain and spinal cord via an extensive branching system, where they release norepinephrine to regulate heartbeat, blood pressure, arousal, memory, and attention." "In Parkinson’s, the locus coeruleus is one of the first brain regions
"Nerve cells originating in the locus coeruleus extend throughout the brain and spinal cord via an extensive branching system, where they release norepinephrine to regulate heartbeat, blood pressure, arousal, memory, and attention." "In Parkinson’s, the locus coeruleus is one of the first brain regions
jeffreyn
in
Cure Parkinson's
6 months ago
Lupus rash?
I have suffered many different symptoms for a period approaching 15 years. About 4 years ago my GP said that I had too many symptoms across multiple systems and there was nothing more he could do for me. He referred me to the hospital but I’m still waiting four years down the line. I discussed Lupus
I have suffered many different symptoms for a period approaching 15 years. About 4 years ago my GP said that I had too many symptoms across multiple systems and there was nothing more he could do for me. He referred me to the hospital but I’m still waiting four years down the line. I discussed Lupus
Dontknowwhattodo
in
LUPUS UK
1 month ago
What is my status
Please could someone clarify this for me as had an overactive thyroid which was knocked out with RAI. I am Thyroxine which, thank goodness, has stabilised me so that I am Euthyridic (sp) however there are the occasional flareups of eye problems associated with Throid Eye Disease. What I am really confused
Please could someone clarify this for me as had an overactive thyroid which was knocked out with RAI. I am Thyroxine which, thank goodness, has stabilised me so that I am Euthyridic (sp) however there are the occasional flareups of eye problems associated with Throid Eye Disease. What I am really confused
JennyWrenn4
in
Thyroid UK
4 months ago
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Good news on memory following B12 treatment
Hi, some of the regular posters may remember me posting in absolute despair last autumn about my husband’s cognitive issues and extreme memory loss. I’m now posting an update in case it helps anyone else in his position. In summary he had experienced symptoms over a couple of decades since he was twenty
Hi, some of the regular posters may remember me posting in absolute despair last autumn about my husband’s cognitive issues and extreme memory loss. I’m now posting an update in case it helps anyone else in his position. In summary he had experienced symptoms over a couple of decades since he was twenty
Zmalp
in
Pernicious Anaemia Society
1 month ago
Update-Covid antiviral
This evening I finally got the call from a consultant from , Stoke Mandeville hospital.Booked in for liver and kidney blood test and infusion .... what a relief . Just want to feel better. Thank you all for your advice and care. 😊
This evening I finally got the call from a consultant from , Stoke Mandeville hospital.Booked in for liver and kidney blood test and infusion .... what a relief . Just want to feel better. Thank you all for your advice and care. 😊
Stavrou1
in
CLL Support
6 months ago
Declining psa #8
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Nfler
in
Advanced Prostate Cancer
6 months ago
knocked sideways
Ive been reading all your posts but not actually written anything for a while because in my stupid head I thought we were plodding along even if it was at a plateau level. Kev was diagnosed with non alcoholic liver cirrhosis back in July. He also had sepsis twice and ended up in intensive care where
Ive been reading all your posts but not actually written anything for a while because in my stupid head I thought we were plodding along even if it was at a plateau level. Kev was diagnosed with non alcoholic liver cirrhosis back in July. He also had sepsis twice and ended up in intensive care where
Snips71
in
Liver4Life
6 months ago
combining standard PCA care with alternative care
In a three month period my PSA went from 58 to 70. Obviously my testosterone was producing more new cancer cells than my alternative treatment. I started the combination treatment on Dec 1 by taking 2 ORGOVYX. Dec 15 my PSA is 27.5 and I will take one more ORGOVYX today hoping to reduce PSA to 10
In a three month period my PSA went from 58 to 70. Obviously my testosterone was producing more new cancer cells than my alternative treatment. I started the combination treatment on Dec 1 by taking 2 ORGOVYX. Dec 15 my PSA is 27.5 and I will take one more ORGOVYX today hoping to reduce PSA to 10
agnut
in
Fight Prostate Cancer
6 months ago
Blood test positive lupus
Recently had bloods done due to a few skin rashes and I looked at the results and some say lupus positive I need more bloods done tomorrow but haven't spoke to the doctor yet but looked online about lupus and a lot of what I'm having seems to all add up to lupus my head is all over the place
Recently had bloods done due to a few skin rashes and I looked at the results and some say lupus positive I need more bloods done tomorrow but haven't spoke to the doctor yet but looked online about lupus and a lot of what I'm having seems to all add up to lupus my head is all over the place
Debz1974
in
LUPUS UK
2 months ago
Parathyroid
I am booked in for a Parathyroidectomy and I just wondered whether my APS, as an autoimmune disease, could have had something to do with parathyroid condition? Thank you.
I am booked in for a Parathyroidectomy and I just wondered whether my APS, as an autoimmune disease, could have had something to do with parathyroid condition? Thank you.
Raschen
in
Hughes Syndrome APS Forum
2 months ago
PSA on the rise
Good morning everyone, my PSA has been undectable, {<.01} since July 2022. Not real long, but it has been a good time. Felt good, no pain, can look on my profile for more details. I am on Xtandi and Lupron--(3 months). (I had taxetere in 2021) I get my PSA checked every three months right before
Good morning everyone, my PSA has been undectable, {<.01} since July 2022. Not real long, but it has been a good time. Felt good, no pain, can look on my profile for more details. I am on Xtandi and Lupron--(3 months). (I had taxetere in 2021) I get my PSA checked every three months right before
JD-guy
in
Advanced Prostate Cancer
6 months ago
Blood results help
Hi I have had blood test tsh is one (range 0.4 to 5) and T4 is 14 ( range is 9 to 19). Also had an ultrasound which showed altered echotexture but no enlargement of thyroid. Are these results OK? Have symptoms of underactive thyroid but results all in range. Thanks
Hi I have had blood test tsh is one (range 0.4 to 5) and T4 is 14 ( range is 9 to 19). Also had an ultrasound which showed altered echotexture but no enlargement of thyroid. Are these results OK? Have symptoms of underactive thyroid but results all in range. Thanks
Lolly2564
in
Thyroid UK
2 months ago
Other blood results
I now have more results Serum folate 14.3 (3.1-17.5) Ferritin 138 (13-150) Iron 14 (5-28) B12 280 (200-940) Since they are in the range ‘everything is normal’! The coeliac one was clear so I can now try gluten free for 3 months to see if it makes any changes. But I am still tired, muscle aches
I now have more results Serum folate 14.3 (3.1-17.5) Ferritin 138 (13-150) Iron 14 (5-28) B12 280 (200-940) Since they are in the range ‘everything is normal’! The coeliac one was clear so I can now try gluten free for 3 months to see if it makes any changes. But I am still tired, muscle aches
Purple450
in
Thyroid UK
2 months ago
new member
hi everyone l joined this group today was wondering could l get any advice, am 38 been recently diagnosed with underactive thyroid l am currently on 100mg of Lev tablets but l still feel tired l have put on so much weigh in past few years and didn’t know what was causing it, I have bought the semuglutide
hi everyone l joined this group today was wondering could l get any advice, am 38 been recently diagnosed with underactive thyroid l am currently on 100mg of Lev tablets but l still feel tired l have put on so much weigh in past few years and didn’t know what was causing it, I have bought the semuglutide
Preciouspearl
in
Thyroid UK
2 months ago
Lupus re-diagnosis UCTD
Hello All, so when I last posted I had been to the rheumatologist Prof X and told my bloods were not suggestive of lupus but he did not suggest want condition could be the underlying cause of my symptoms. This morning he chose not to see me, instead I saw a very nice female doctor in clinical research
Hello All, so when I last posted I had been to the rheumatologist Prof X and told my bloods were not suggestive of lupus but he did not suggest want condition could be the underlying cause of my symptoms. This morning he chose not to see me, instead I saw a very nice female doctor in clinical research
KeepingUpBeat
in
LUPUS UK
2 months ago
National Bill to End Parkinson's
Hello, I'll keep it short and sweet. 55 yr male. Diagnosed at 42 yr. Fitness fanatic, which has kept this damn disease at bay......for the most part. Just wondering what everyone thinks of this new Bill to End Parkinson's Act. Should we be excited, worried, indifferent? Is it gonna just be all talk and
Hello, I'll keep it short and sweet. 55 yr male. Diagnosed at 42 yr. Fitness fanatic, which has kept this damn disease at bay......for the most part. Just wondering what everyone thinks of this new Bill to End Parkinson's Act. Should we be excited, worried, indifferent? Is it gonna just be all talk and
Metalovinshaker13
in
Cure Parkinson's
6 months ago
PSA post Salvage Radiation
Prior post: My husband, at diagnosis had 3+4 on a couple of samples and chose to have surgery. He had clean margins and reached undetectable PSA after Prostatectomy. Near the end of 5th year after surgery his PSA became detectable. He did salvage radiation at .09 PSA. His PSA went down to .08 after
Prior post: My husband, at diagnosis had 3+4 on a couple of samples and chose to have surgery. He had clean margins and reached undetectable PSA after Prostatectomy. Near the end of 5th year after surgery his PSA became detectable. He did salvage radiation at .09 PSA. His PSA went down to .08 after
Silverlings
in
Advanced Prostate Cancer
6 months ago
Study: Depression is largely prevalent, but undiagnosed in SLEResearchers in Pakistan surveyed 40 people with SLE using PHQ-9 scale
Depression is highly prevalent among people with systemic lupus erythematosus (SLE), but often goes undiagnosed, according to a single center study in Pakistan. The “treatment of depression is a vital component in the management of these patients and should be offered where appropriate,” the researchers
Depression is highly prevalent among people with systemic lupus erythematosus (SLE), but often goes undiagnosed, according to a single center study in Pakistan. The “treatment of depression is a vital component in the management of these patients and should be offered where appropriate,” the researchers
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 months ago
I wonder how many of us have this gene snip?It seems responsible for some autoimmune Thyroid disease and is quite rare
I have my nebula genomics results and this snip in particular seems relevant . Does anyone else have their results? Snip rs2476601 it says in snpedia.com that it is bad to have an A and very rare to have 2 AA Can cause lots of other autoimmune diseases too Best wishes Manjushri
I have my nebula genomics results and this snip in particular seems relevant . Does anyone else have their results? Snip rs2476601 it says in snpedia.com that it is bad to have an A and very rare to have 2 AA Can cause lots of other autoimmune diseases too Best wishes Manjushri
Manjushri
in
Thyroid UK
2 months ago
T3 when to take it
have been put on a T3 trial by a private doctor who specialises in thyroid conditions, just wondered what time of day morning and evening is best to take it, as have been told to take it twice a day. Been on thyroid medication for over 70 years. For a underactive thyroid. As members say the thyroid
have been put on a T3 trial by a private doctor who specialises in thyroid conditions, just wondered what time of day morning and evening is best to take it, as have been told to take it twice a day. Been on thyroid medication for over 70 years. For a underactive thyroid. As members say the thyroid
elwins
in
Thyroid UK
2 months ago
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